{"id":"W4377136766","doi":"10.18632/aging.204738","title":"Plasma exosome proteomics reveals the pathogenesis mechanism of post-stroke cognitive impairment","year":2023,"lang":"en","type":"article","venue":"Aging","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"China Academy of Chinese Medical Sciences; Beijing University of Chinese Medicine; National Natural Science Foundation of China","keywords":"Exosome; Proteomics; Biomarker; Western blot; Pathogenesis; Blood proteins; Microvesicles; Internal medicine; Quantitative proteomics; Medicine; Endocrinology; Biology; Biochemistry; microRNA; Gene","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003164622,0.0005280733,0.0004524823,0.0009082301,0.0002432287,0.0005825681,0.000187544,0.0003962914,0.001105508],"category_scores_gemma":[0.0005029452,0.000156877,0.0003218637,0.000456073,0.0002720662,0.0003979937,0.0003748841,0.0003755084,0.0001933969],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002692532,"about_ca_system_score_gemma":0.0001639864,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006137087,"about_ca_topic_score_gemma":0.0004752079,"domain_scores_codex":[0.9998621,0.0000267208,0.00002071261,0.00003472105,0.00003080504,0.00002497936],"domain_scores_gemma":[0.999787,0.00002450438,0.0001060056,0.00001500153,0.0000391911,0.00002828955],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.007926409,0.0004796784,0.5711551,0.0005967966,0.000683377,0.004222327,0.0007675281,0.0005809973,0.3407752,0.0006609475,0.001262959,0.07088865],"study_design_scores_gemma":[0.00004245066,0.0007091979,0.9624552,0.00004530513,0.0002259528,0.003424961,0.0003839734,0.002025943,0.0284755,0.0009878112,0.001200739,0.00002301553],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954132,0.002520283,0.001169046,0.0001112473,0.00001133536,0.00001714331,0.0002537601,0.00002520132,0.0004788237],"genre_scores_gemma":[0.9978136,0.0008038001,0.0004737702,0.00006568924,0.00001414875,0.00001832286,0.0002457139,0.000004015496,0.0005608888],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001105508,"threshold_uncertainty_score":0.003698349,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009799930363798701,"score_gpt":0.2433398274024645,"score_spread":0.2335398970386658,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}