{"id":"W4377137364","doi":"10.1007/s10875-023-01512-9","title":"Autoantibodies Neutralizing Type I IFNs in the Bronchoalveolar Lavage of at Least 10% of Patients During Life-Threatening COVID-19 Pneumonia","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical Immunology","topic":"COVID-19 Clinical Research Studies","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Center for Advancing Translational Sciences; National Institutes of Health; Howard Hughes Medical Institute; Agence Nationale de la Recherche; National Institute of Allergy and Infectious Diseases; European Respiratory Society; Fondation pour la Recherche Médicale","keywords":"Bronchoalveolar lavage; Pneumonia; Medicine; Immunology; Autoantibody; Neutralizing antibody; Virology; Antibody; Lung; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002658858,0.000424029,0.0004966657,0.000380124,0.0005649019,0.0005920635,0.0002445763,0.0006110458,0.001240132],"category_scores_gemma":[0.001833395,0.0003287942,0.0002734788,0.0002338864,0.0004242963,0.0004359191,0.0003309532,0.0005843981,0.000275016],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002678179,"about_ca_system_score_gemma":0.0001731323,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001599795,"about_ca_topic_score_gemma":0.00110476,"domain_scores_codex":[0.9994577,0.00009106484,0.00007633682,0.0001213966,0.0001163886,0.000137091],"domain_scores_gemma":[0.999319,0.0001720671,0.0002158782,0.0000503027,0.0001173127,0.0001254438],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002221189,0.00003606094,0.9875956,0.00003207641,0.00003519654,0.002548301,0.0003395782,0.00004086434,0.005969374,0.00001635836,0.0001964675,0.002968134],"study_design_scores_gemma":[0.00001246449,0.0004308573,0.9831365,0.00002691552,0.00004913724,0.01296724,0.0006365467,0.0001797388,0.001837763,0.00002539435,0.0006895325,0.000008009395],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998793,0.0004650392,0.00008546306,0.00003665044,0.00001361527,0.000008138328,0.00005498888,0.000006729585,0.0005363902],"genre_scores_gemma":[0.9996828,0.00009252883,0.00003618829,0.00005396088,0.00000972914,0.000003070181,0.00005603381,0.00000125954,0.00006440343],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001599795,"threshold_uncertainty_score":0.004148662,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1337295934069382,"score_gpt":0.4875512252266433,"score_spread":0.3538216318197052,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}