{"id":"W4377139575","doi":"10.1186/s12951-023-01928-w","title":"Detoxified synthetic bacterial membrane vesicles as a vaccine platform against bacteria and SARS-CoV-2","year":2023,"lang":"en","type":"article","venue":"Journal of Nanobiotechnology","topic":"Bacterial Infections and Vaccines","field":"Immunology and Microbiology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital","funders":"Sahlgrenska Akademin; Göteborgs Universitet; Vetenskapsrådet; Hjärt-Lungfonden","keywords":"Microbiology; Pseudomonas aeruginosa; Immunization; Immune system; Bacterial outer membrane; Immunity; Vesicle; Escherichia coli; Biology; Bacteria; Bacterial cell structure; Antigen; Virology; Immunology; Membrane; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004082886,0.0002564635,0.0006405641,0.0007494144,0.0001990265,0.00004266922,0.0003025119,0.0006982562,0.000238732],"category_scores_gemma":[0.0002246794,0.0002059206,0.000143165,0.0003974276,0.0001478604,0.0002235106,0.0001795426,0.000535944,0.0004163043],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004281839,"about_ca_system_score_gemma":0.0000798977,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003185868,"about_ca_topic_score_gemma":0.00002842939,"domain_scores_codex":[0.9984897,0.00008668232,0.0007100881,0.0002505793,0.0000271588,0.000435767],"domain_scores_gemma":[0.9989546,0.00014094,0.0004676258,0.0002831056,0.0001254323,0.00002828067],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000554931,0.0000605993,0.00009474745,0.00002018626,0.000232357,0.00003378116,0.0000727504,5.61748e-7,0.9801506,0.0005557886,0.001478986,0.01674465],"study_design_scores_gemma":[0.002323612,0.0006204016,0.001444754,0.00006467022,0.00007293185,0.002444614,0.0001224423,0.000003138164,0.8950173,0.0004973641,0.09719331,0.0001954172],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938508,0.0003736199,0.00001324334,0.002453257,0.002867487,0.0001514946,0.000020467,0.0001840927,0.00008554071],"genre_scores_gemma":[0.9980254,0.001402499,0.00009162186,0.00008462957,0.0001810925,0.00000589358,0.00002339766,0.00003115526,0.0001542962],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09571432,"threshold_uncertainty_score":0.8397199,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01867813429684724,"score_gpt":0.2572764922412134,"score_spread":0.2385983579443662,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}