{"id":"W4377139575","doi":"10.1186/s12951-023-01928-w","title":"Detoxified synthetic bacterial membrane vesicles as a vaccine platform against bacteria and SARS-CoV-2","year":2023,"lang":"en","type":"article","venue":"Journal of Nanobiotechnology","topic":"Bacterial Infections and Vaccines","field":"Immunology and Microbiology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital","funders":"Sahlgrenska Akademin; Göteborgs Universitet; Vetenskapsrådet; Hjärt-Lungfonden","keywords":"Microbiology; Pseudomonas aeruginosa; Immunization; Immune system; Bacterial outer membrane; Immunity; Vesicle; Escherichia coli; Biology; Bacteria; Bacterial cell structure; Antigen; Virology; Immunology; Membrane; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000116814,0.0002436212,0.0001759444,0.0001408817,0.0000893697,0.0002664413,0.0001396184,0.0003030378,0.0002512788],"category_scores_gemma":[0.00009861854,0.00009779977,0.000207106,0.00007150945,0.0001288511,0.0003190554,0.0002215503,0.0002861051,0.0001161355],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001857103,"about_ca_system_score_gemma":0.0001579403,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002220557,"about_ca_topic_score_gemma":0.0003141779,"domain_scores_codex":[0.9999301,0.00001523428,0.000005466009,0.00001094143,0.00002061586,0.00001751587],"domain_scores_gemma":[0.999962,0.000003999241,0.00001519614,0.000003055418,0.000007825348,0.000007982406],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002175813,0.00001129982,0.00006166965,0.00002758061,0.000003271805,0.00002321061,0.000006507668,0.0001670216,0.998329,0.0001883019,0.00001194539,0.001148539],"study_design_scores_gemma":[0.000007419706,0.0002641754,0.0004275559,0.000005744949,0.000009211386,0.0001062662,0.00001366266,0.001007635,0.9963387,0.00005091537,0.001764897,0.000003860962],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9846806,0.001921467,0.01223466,0.0001077276,0.00003833485,0.00005275059,0.00008121604,0.00005438725,0.0008288595],"genre_scores_gemma":[0.9915793,0.0009423618,0.006098452,0.00004378798,0.000006574806,0.00003136661,0.0001567514,0.00001147072,0.001129895],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0003030378,"threshold_uncertainty_score":0.001347423,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01867813429684724,"score_gpt":0.2572764922412134,"score_spread":0.2385983579443662,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}