{"id":"W4377140711","doi":"10.1111/epi.17659","title":"<i>kcna1a</i> mutant zebrafish model episodic ataxia type 1 (EA1) with epilepsy and show response to first‐line therapy carbamazepine","year":2023,"lang":"en","type":"article","venue":"Epilepsia","topic":"Zebrafish Biomedical Research Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotchkiss Brain Institute; Alberta Children's Hospital; University of Calgary","funders":"","keywords":"Zebrafish; Epilepsy; Ataxia; Neuroscience; Carbamazepine; Biology; Startle response; Internal medicine; Medicine; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001461041,0.0007828533,0.000444928,0.0005484944,0.0003318897,0.0002496401,0.0003816239,0.0006659774,0.003329411],"category_scores_gemma":[0.0001291967,0.0002292725,0.0006309141,0.0001747977,0.000507842,0.0002701578,0.0002613124,0.001002166,0.0008991268],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007953198,"about_ca_system_score_gemma":0.0004791138,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006140041,"about_ca_topic_score_gemma":0.01061498,"domain_scores_codex":[0.9997717,0.00001208873,0.00003292111,0.00006879715,0.00007368753,0.00004095102],"domain_scores_gemma":[0.999799,0.00001411478,0.00008809,0.00001385408,0.00002864302,0.00005645346],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000101826,0.00002603494,0.0002069988,0.00004915973,0.000008204282,0.0001470097,0.00001563025,0.00008261154,0.998368,0.00007127545,0.0001342778,0.000788886],"study_design_scores_gemma":[0.00008888279,0.0008733585,0.01267491,0.00003990258,0.0001089604,0.001707036,0.0001208453,0.001966408,0.9771563,0.0001219404,0.005099867,0.00004162584],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9823715,0.00119839,0.006280446,0.0005841369,0.000162522,0.0001600599,0.004833509,0.0006944701,0.003714866],"genre_scores_gemma":[0.9750259,0.001175459,0.007760954,0.0002668402,0.00001664535,0.0003191576,0.002196717,0.0001892297,0.01304907],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006140041,"threshold_uncertainty_score":0.01220864,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02062603038918052,"score_gpt":0.2873514648662416,"score_spread":0.2667254344770611,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}