{"id":"W4377140711","doi":"10.1111/epi.17659","title":"<i>kcna1a</i> mutant zebrafish model episodic ataxia type 1 (EA1) with epilepsy and show response to first‐line therapy carbamazepine","year":2023,"lang":"en","type":"article","venue":"Epilepsia","topic":"Zebrafish Biomedical Research Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotchkiss Brain Institute; Alberta Children's Hospital; University of Calgary","funders":"","keywords":"Zebrafish; Epilepsy; Ataxia; Neuroscience; Carbamazepine; Biology; Startle response; Internal medicine; Medicine; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007216876,0.000281753,0.0002699442,0.0001673559,0.000203772,0.00005986561,0.0004281333,0.0002037425,0.00006218893],"category_scores_gemma":[0.0006147129,0.0002329206,0.00006269046,0.0007585444,0.0002602269,0.00000955682,0.000307633,0.0002180876,0.0001872811],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003269597,"about_ca_system_score_gemma":0.0002405402,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005048589,"about_ca_topic_score_gemma":0.0001381776,"domain_scores_codex":[0.9977421,0.0001176306,0.0002869798,0.0007632828,0.0004376768,0.0006523868],"domain_scores_gemma":[0.9982177,0.0001175522,0.00006426295,0.0008471948,0.0001879996,0.0005652988],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.004253529,0.000145208,0.003702701,0.00002842624,0.0001123377,0.00004731186,0.0001379141,0.0007007282,0.894729,0.0001039945,0.09081628,0.005222571],"study_design_scores_gemma":[0.004764703,0.005946687,0.05354853,0.0001180519,0.00004204856,0.0000878251,0.0001155715,0.01861092,0.1922774,0.000882712,0.7223094,0.001296173],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9813245,0.0003427404,0.005619245,0.01131724,0.00005319959,0.000770771,0.0002052033,0.0001126212,0.0002545017],"genre_scores_gemma":[0.9915763,0.001732408,0.001491155,0.001971978,0.0002070646,0.0002936894,0.0004382238,0.00008095729,0.002208271],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7024515,"threshold_uncertainty_score":0.9498227,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02062603038918052,"score_gpt":0.2873514648662416,"score_spread":0.2667254344770611,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}