{"id":"W4377141118","doi":"10.1016/j.toxlet.2023.05.007","title":"Aryl hydrocarbon receptor is regulated via multiple mechanisms in human keratinocytes","year":2023,"lang":"en","type":"article","venue":"Toxicology Letters","topic":"Adipose Tissue and Metabolism","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Research Council Canada; Russian Foundation for Basic Research","keywords":"Aryl hydrocarbon receptor; Aryl hydrocarbon receptor nuclear translocator; MG132; Chemistry; Cell biology; Transcription factor; Gene knockdown; Molecular biology; Proteasome inhibitor; Biology; Biochemistry; Proteasome; Apoptosis; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002342982,0.000201337,0.0004369333,0.0003507245,0.00008793609,0.000007738565,0.0001160774,0.0002315249,0.0005682494],"category_scores_gemma":[0.00006136308,0.0001960716,0.00008171498,0.0004700909,0.00009923696,0.00005871411,0.00006091497,0.0003130483,0.0006018545],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007017884,"about_ca_system_score_gemma":0.00002440211,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008673062,"about_ca_topic_score_gemma":0.00004281126,"domain_scores_codex":[0.9985403,0.000062185,0.0003310848,0.000397366,0.0001714486,0.0004975623],"domain_scores_gemma":[0.9993698,0.00007729908,0.00007639594,0.000331828,0.00001924833,0.0001254107],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006843657,0.00006796002,0.002475562,0.00001852263,0.00005953125,0.0002379317,0.0007201153,0.00001439373,0.9756486,0.0002140863,0.01939143,0.001083383],"study_design_scores_gemma":[0.004607754,0.00038698,0.06746581,0.00006913918,0.0001217108,0.00007063458,0.0001018284,0.001723907,0.9105378,0.0009335368,0.01358663,0.0003943092],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9804134,0.0001006857,0.0001418217,0.01787075,0.0004080765,0.0004804292,0.000004674186,0.0002901524,0.0002899819],"genre_scores_gemma":[0.9797928,0.00002013479,0.000793194,0.01670317,0.0002173276,0.00006776844,0.0001167996,0.00004615439,0.002242702],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0651109,"threshold_uncertainty_score":0.7995568,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01966052636750953,"score_gpt":0.2743366978165184,"score_spread":0.2546761714490088,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}