{"id":"W4377141625","doi":"10.1016/j.canlet.2023.216242","title":"A costimulatory chimeric antigen receptor targeting TROP2 enhances the cytotoxicity of NK cells expressing a T cell receptor reactive to human papillomavirus type 16 E7","year":2023,"lang":"en","type":"article","venue":"Cancer Letters","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"Occupational Cancer Research Centre; Institute of Cancer Research; University of Calgary","funders":"","keywords":"T-cell receptor; Cytotoxic T cell; Antigen; Chimeric antigen receptor; Biology; Adoptive cell transfer; CD8; Cancer research; T cell; CD28; Cancer immunotherapy; Immunotherapy; CD3; Immunology; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001983857,0.0003956953,0.0004302274,0.0001824936,0.0001556936,0.0004629737,0.0001940168,0.0003991612,0.002205033],"category_scores_gemma":[0.0002297964,0.0001557477,0.0002367212,0.0000952639,0.0002206306,0.0003363613,0.0002310667,0.0007597828,0.0005547096],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002366346,"about_ca_system_score_gemma":0.0002206798,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000336043,"about_ca_topic_score_gemma":0.0004092804,"domain_scores_codex":[0.9997672,0.00006027283,0.00001422159,0.00002369859,0.00003846594,0.00009613932],"domain_scores_gemma":[0.9998209,0.00008450577,0.00001733009,0.00002219504,0.00001570439,0.00003942004],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005376126,0.0001021676,0.0002133483,0.00002702412,0.000004821249,0.0001207892,0.00002128028,0.0001698324,0.9972942,0.0001045032,0.00006122974,0.00134307],"study_design_scores_gemma":[0.0001549949,0.001856432,0.00440406,0.000007541581,0.00002676889,0.0007520792,0.00005954335,0.002017768,0.9887264,0.00005992165,0.0019265,0.00000808418],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974692,0.0003170373,0.0003049337,0.00003801718,0.00001842168,0.0000118812,0.00003598763,0.00002669438,0.001777949],"genre_scores_gemma":[0.9979493,0.0001627049,0.000257078,0.00003460179,0.00001368301,0.00001034998,0.00008148597,0.00001003941,0.001480766],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002205033,"threshold_uncertainty_score":0.007376611,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0350265985775997,"score_gpt":0.3340917778599455,"score_spread":0.2990651792823458,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}