{"id":"W4377194529","doi":"10.1016/j.adro.2023.101273","title":"The Pediatric Proton and Photon Therapy Comparison Cohort: Study Design for a Multicenter Retrospective Cohort to Investigate Subsequent Cancers After Pediatric Radiation Therapy","year":2023,"lang":"en","type":"article","venue":"Advances in Radiation Oncology","topic":"Radiation Therapy and Dosimetry","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"National Cancer Institute; Genentech; Novocure; National Institutes of Health; Varian Medical Systems","keywords":"Medicine; Proton therapy; Cohort; Record linkage; Pediatric cancer; Cohort study; Retrospective cohort study; Radiation therapy; Confounding; Cancer; Incidence (geometry); Proportional hazards model; Pediatrics; Internal medicine; Environmental health; Population","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00190743,0.0002893878,0.0005890236,0.0005613707,0.0002632445,0.00005011468,0.0001455979,0.00017132,0.00002439506],"category_scores_gemma":[0.0003897477,0.0002257378,0.00007627705,0.001377327,0.00008398741,0.0003129792,0.00002057768,0.0002720321,0.00001689943],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00123736,"about_ca_system_score_gemma":0.0003763049,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007992094,"about_ca_topic_score_gemma":0.0001008263,"domain_scores_codex":[0.997241,0.0005012859,0.0007247776,0.0006481897,0.000401237,0.0004834709],"domain_scores_gemma":[0.9978843,0.001017704,0.0004082199,0.0003198435,0.0001764163,0.0001934834],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003737959,0.0002718178,0.9647461,0.00002485845,0.00008429932,0.000007105779,0.002666937,0.002275451,0.00005146585,0.00001541312,0.0004004174,0.02571815],"study_design_scores_gemma":[0.00784074,0.003627707,0.96852,0.000005433143,0.00007839366,0.000002423018,0.0002944774,0.005978746,0.000606728,0.0002401671,0.01257021,0.0002349972],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9692689,0.01157066,0.0004510329,0.0008548807,0.0008270739,0.01685185,0.00001775997,0.0001162718,0.00004161902],"genre_scores_gemma":[0.9164963,0.06956746,0.0003510403,0.0009083099,0.0005403699,0.01198738,0.00003501544,0.00004592075,0.00006813104],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05799681,"threshold_uncertainty_score":0.920532,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02653078034985086,"score_gpt":0.3692408829384503,"score_spread":0.3427101025885994,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}