{"id":"W4377233682","doi":"10.1002/chem.202300982","title":"Potent and Selective Cell‐Active Iminosugar Inhibitors of Human α‐<i>N</i>‐Acetylgalactosaminidase (α‐NAGAL)","year":2023,"lang":"en","type":"article","venue":"Chemistry - A European Journal","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Natural Sciences and Engineering Research Council of Canada; Junta de Andalucía; Ministerio de Ciencia e Innovación; Agencia Estatal de Investigación; Canada Research Chairs; Michael Smith Health Research BC; European Regional Development Fund; Universidad de Sevilla","keywords":"Iminosugar; Cell; Chemistry; Cell biology; Biochemistry; Biology; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001016533,0.0004567809,0.0001497995,0.0001034373,0.00007947715,0.0001785421,0.00018209,0.0001479861,0.0004059062],"category_scores_gemma":[0.0000686915,0.00008781278,0.0001367032,0.00009620713,0.0001106943,0.00009669366,0.0001262723,0.000314242,0.0001935045],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002460287,"about_ca_system_score_gemma":0.0001329068,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004444842,"about_ca_topic_score_gemma":0.0009723387,"domain_scores_codex":[0.9999229,0.00001522122,0.000007794103,0.00001346749,0.00002145471,0.00001926956],"domain_scores_gemma":[0.9999679,0.000007140033,0.000009310662,0.000003673685,0.000004869614,0.000007066082],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003721662,0.00001555465,0.00003791921,0.0000174648,0.000002393788,0.0000194778,0.000007626125,0.00007978156,0.9983089,0.00008022301,0.00003491503,0.001358546],"study_design_scores_gemma":[0.000009473511,0.000160396,0.0003498021,0.000001422191,0.000004696321,0.00007135146,0.0000040167,0.0004215331,0.9976786,0.00001020689,0.001287388,0.000001277829],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9778752,0.003438542,0.0121805,0.00009347666,0.00004500626,0.0001109615,0.0004610748,0.0001323273,0.005662835],"genre_scores_gemma":[0.9875433,0.001910874,0.007496447,0.00004836938,0.0000133027,0.00006858697,0.0004668092,0.00001953107,0.002432768],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004567809,"threshold_uncertainty_score":0.0017851,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01322654779369409,"score_gpt":0.212296403875179,"score_spread":0.1990698560814849,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}