{"id":"W4377290765","doi":"10.1073/pnas.2302019120","title":"Stem cell decoupling underlies impaired lymphoid development during aging","year":2023,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Heart, Lung, and Blood Institute; National Institutes of Health; Institut National Du Cancer; York University; New York State Stem Cell Science; Edward P. Evans Foundation; European Hematology Association; National Institute on Aging; Damon Runyon Cancer Research Foundation","keywords":"Biology; Haematopoiesis; Myeloid; Lymphopoiesis; Stem cell; Bone marrow; Population; Progenitor cell; Immunophenotyping; Hematopoietic stem cell; Cell biology; Immunology; Flow cytometry; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001499992,0.0002713393,0.0003052328,0.0002976805,0.0001144047,0.0002803764,0.0001672517,0.0002075464,0.0004839556],"category_scores_gemma":[0.00008914348,0.0001538109,0.0002090606,0.0001326305,0.0002559235,0.0001891782,0.0002649695,0.0003316221,0.0001739358],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001610429,"about_ca_system_score_gemma":0.0001359036,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003003511,"about_ca_topic_score_gemma":0.0005593979,"domain_scores_codex":[0.9999048,0.000008213252,0.000007592186,0.0000350199,0.00002624311,0.00001812795],"domain_scores_gemma":[0.9998794,0.00000748008,0.00005085266,0.00001153479,0.000013088,0.00003757784],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003460332,0.000002552529,0.0006576132,0.00001022831,0.000003541883,0.00003528029,0.0000104221,0.00002280693,0.9985818,0.0000559659,0.0000122994,0.0005728345],"study_design_scores_gemma":[0.00001154106,0.0002023619,0.1522414,0.00001021844,0.00005285319,0.0008003692,0.00008543697,0.00155743,0.8418319,0.0004380457,0.002754628,0.00001382853],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992755,0.001020332,0.00475488,0.0000397625,0.00001371267,0.00001050684,0.0006518147,0.000127211,0.0006267531],"genre_scores_gemma":[0.996103,0.0004653888,0.001602386,0.00005362483,0.00001028063,0.00001620872,0.0005183857,0.00002993328,0.001200718],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004839556,"threshold_uncertainty_score":0.001618981,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03982648282139958,"score_gpt":0.2701151427250139,"score_spread":0.2302886599036143,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}