{"id":"W4377292084","doi":"10.1016/j.ccrj.2023.04.008","title":"Protocol and statistical analysis plan for the mega randomised registry trial comparing conservative vs. liberal oxygenation targets in adults with sepsis in the intensive care unit (Mega-ROX Sepsis)","year":2023,"lang":"en","type":"article","venue":"Critical Care and Resuscitation","topic":"Sepsis Diagnosis and Treatment","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Alberta Health Services","funders":"Intensive Care Society; Health Research Council of New Zealand; Alberta Health Services","keywords":"Medicine; Sepsis; Mechanical ventilation; Intensive care unit; Emergency medicine; Intensive care medicine; Clinical trial; Randomized controlled trial; Mortality rate; Surgery; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.1128264,0.006148273,0.009375081,0.004908567,0.002952713,0.006061465,0.003725041,0.008645522,0.1280453],"category_scores_gemma":[0.2143801,0.004082244,0.008305784,0.006498485,0.004149927,0.003307534,0.002756273,0.01366469,0.02345985],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.006297104,"about_ca_system_score_gemma":0.01834748,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002224369,"about_ca_topic_score_gemma":0.003271141,"domain_scores_codex":[0.8817229,0.08742175,0.01275486,0.005420775,0.009293645,0.00338602],"domain_scores_gemma":[0.9073244,0.04436251,0.01387263,0.01624763,0.01440937,0.003783521],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.4167899,0.003285715,0.001904878,0.0651743,0.00800741,0.0009343711,0.001242978,0.007887471,0.003046351,0.04092425,0.3635074,0.08729491],"study_design_scores_gemma":[0.5980519,0.01114981,0.004856619,0.02326316,0.004488193,0.0004381819,0.0003499243,0.01896407,0.003605656,0.04382373,0.2904527,0.0005560942],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.0005885632,0.0002427679,0.009187527,0.0009773996,0.001554702,0.9752011,0.009354602,0.0004949018,0.002398432],"genre_scores_gemma":[0.001026686,0.00008244326,0.009638829,0.0003959691,0.0001199477,0.9872741,0.0006911413,0.00003951512,0.0007315054],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.1280453,"threshold_uncertainty_score":0.5966902,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1037823662267893,"score_gpt":0.4005427787807914,"score_spread":0.2967604125540021,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}