{"id":"W4377564821","doi":"10.3390/jox13020016","title":"Incubation Time Influences Organic Anion Transporter 1 Kinetics and Renal Clearance Predictions","year":2023,"lang":"en","type":"article","venue":"Journal of Xenobiotics","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Canadian Institutes of Health Research","keywords":"Probenecid; Chemistry; Incubation; Pharmacokinetics; Potency; Organic anion transporter 1; Pharmacology; Incubation period; Steady state (chemistry); Transporter; Kinetics; Excretion; Michaelis–Menten kinetics; Renal physiology; In vitro; Biochemistry; Renal function; Biology; Enzyme; Enzyme assay","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002273692,0.00009624762,0.0002309241,0.0001808172,0.00005994898,0.00001596214,0.00005821859,0.00009652904,0.00007569681],"category_scores_gemma":[0.0000220561,0.00007411373,0.00007044102,0.0003497582,0.00006580516,0.0001117895,0.000005023252,0.0002175336,0.00002110526],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002932917,"about_ca_system_score_gemma":0.00005968379,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":5.060336e-7,"about_ca_topic_score_gemma":0.000004392043,"domain_scores_codex":[0.9990301,0.00001437723,0.0004127071,0.00009165156,0.0003051746,0.0001460464],"domain_scores_gemma":[0.9994074,0.00002380874,0.0001779026,0.00008966276,0.0001810895,0.0001201044],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0007399729,0.0003528612,0.02695204,0.0003215266,0.000283516,0.0004578364,0.001923469,0.000817019,0.9619595,0.0002636489,0.002156767,0.003771822],"study_design_scores_gemma":[0.002960822,0.002229227,0.9485409,0.0008493852,0.000787857,0.0006152646,0.0004627232,0.002078749,0.03350837,0.001353807,0.006349443,0.0002634299],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944634,0.0001940904,0.00339181,0.001376076,0.0002599612,0.0001005365,0.00001002943,0.00004152844,0.0001626128],"genre_scores_gemma":[0.9968978,0.0007265263,0.001274532,0.0001001969,0.0002659826,2.732165e-7,0.00001315714,0.00001769349,0.0007038506],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9284512,"threshold_uncertainty_score":0.302227,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009309165411845113,"score_gpt":0.235103472035391,"score_spread":0.2257943066235459,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}