{"id":"W4377565319","doi":"10.1007/s12022-023-09776-y","title":"Progress in Adrenal Cortical Neoplasms: From Predictive Histomorphology to FLCN-Driven Germline Pathogenesis and the Prognostic Performance of Multiparameter Scoring Systems in Pediatric Adrenal Cortical Neoplasms","year":2023,"lang":"en","type":"letter","venue":"Endocrine Pathology","topic":"Adrenal and Paraganglionic Tumors","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto General Hospital; University of Toronto; University Health Network","funders":"","keywords":"Germline; Medicine; Pathogenesis; Pathology; Biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0006508227,0.0007200616,0.002203614,0.0009999662,0.00008771459,0.00002174092,0.0003505107,0.0006358158,0.00003795299],"category_scores_gemma":[0.001658538,0.0005267279,0.0002133788,0.0008735377,0.001225311,0.00007514739,0.00047618,0.003282364,0.00008090049],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001879836,"about_ca_system_score_gemma":0.0003132309,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002663652,"about_ca_topic_score_gemma":0.00008664689,"domain_scores_codex":[0.9938173,0.001252086,0.00175978,0.001267302,0.0006630291,0.001240556],"domain_scores_gemma":[0.9945484,0.003848465,0.0004754225,0.0006466768,0.0002364431,0.0002445898],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.007646202,0.0004685285,0.7682495,0.001204242,0.0002101505,0.2119719,0.001667515,0.000995252,0.00008992082,0.00004121113,0.00659571,0.000859873],"study_design_scores_gemma":[0.01178844,0.003107093,0.9283019,0.001148749,0.001237878,0.03465416,0.0001850552,0.01786994,0.00008034357,0.00002199,0.0008343681,0.0007700655],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9747536,0.002814658,0.0001237384,0.01816034,0.001191028,0.002464427,0.0003663742,0.0001014576,0.00002440313],"genre_scores_gemma":[0.985024,0.0002815262,0.000976412,0.009284855,0.002229842,0.001291289,0.0005968268,0.0001373969,0.0001777973],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1773178,"threshold_uncertainty_score":0.9997184,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01578150757162048,"score_gpt":0.2554837783800381,"score_spread":0.2397022708084176,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}