{"id":"W4377692745","doi":"10.7554/elife.88058.1","title":"Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domain","year":2023,"lang":"en","type":"preprint","venue":"","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of Victoria","funders":"","keywords":"Allosteric regulation; Protein subunit; Phosphorylation; Chemistry; Protein kinase domain; Cell biology; Protein kinase C; Biophysics; Biochemistry; Receptor; Biology; Mutant; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007379126,0.0001590633,0.00009028831,0.00005176908,0.00009105446,0.0001300292,0.0001894701,0.0001400878,0.00115743],"category_scores_gemma":[0.00006873842,0.00006805429,0.0001415205,0.00004806321,0.0002302019,0.0001183008,0.0001310347,0.0004479548,0.0001872365],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001845448,"about_ca_system_score_gemma":0.00007720726,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001511771,"about_ca_topic_score_gemma":0.000181565,"domain_scores_codex":[0.9999526,0.000005667553,0.000003969939,0.00001373978,0.00001288465,0.00001125039],"domain_scores_gemma":[0.9999703,0.000006674523,0.000009192511,0.000005962601,0.000002324993,0.000005538812],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000600325,0.00001450884,0.00005744299,0.000020539,0.000002193967,0.00001555647,0.000005765343,0.00004485635,0.9992054,0.0001224248,0.00001857917,0.0004326887],"study_design_scores_gemma":[0.00000864675,0.00007242031,0.0006829922,0.000002080753,0.000004273542,0.0000480378,0.000007139889,0.0005813502,0.9978662,0.00003607402,0.0006893619,0.000001337292],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950951,0.0004713305,0.002973583,0.00007557587,0.00002778309,0.00001456804,0.0000738598,0.00004009259,0.001228163],"genre_scores_gemma":[0.9980514,0.0002216067,0.0007542867,0.00004499938,0.000003819239,0.00001586631,0.00005547035,0.000006128083,0.0008464605],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00115743,"threshold_uncertainty_score":0.003871977,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.140507273061632,"score_gpt":0.3834848161702195,"score_spread":0.2429775431085875,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}