{"id":"W4377861442","doi":"10.7554/elife.88058.1.sa1","title":"Reviewer #1 (Public Review): Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domain","year":2023,"lang":"en","type":"peer-review","venue":"","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biological and Environmental Research; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Office of Science; Oregon Health and Science University; U.S. Department of Energy; National Science Foundation; National Institutes of Health; Michael Smith Health Research BC","keywords":"Allosteric regulation; Protein subunit; Phosphorylation; Chemistry; Protein kinase domain; Cell biology; Protein kinase C; Biophysics; Biochemistry; Receptor; Biology; Mutant","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.02255518,0.001533131,0.003086875,0.003022948,0.002763937,0.008402216,0.005318074,0.02248033,0.1232111],"category_scores_gemma":[0.1156652,0.001025053,0.00307964,0.001832479,0.002055733,0.004380061,0.00330522,0.008507168,0.0839216],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.006863378,"about_ca_system_score_gemma":0.01090854,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002719921,"about_ca_topic_score_gemma":0.004177471,"domain_scores_codex":[0.9837102,0.003776936,0.002078818,0.002007587,0.007204094,0.001222495],"domain_scores_gemma":[0.8149258,0.01434559,0.008850652,0.005049607,0.1462439,0.01058444],"domain_codex":null,"domain_gemma":"evaluation","domain_candidate":"evaluation","domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002768632,0.000004869346,0.00003661687,0.0003578356,0.000007465579,0.00001661072,0.000006062103,0.000008616889,0.00002629744,0.00006803392,0.9958627,0.003577151],"study_design_scores_gemma":[0.0001921618,0.00006219991,0.0008241109,0.001582333,0.00004639873,0.000178614,0.0000540311,0.00008943156,0.0001837021,0.0006787869,0.9960718,0.00003646901],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"editorial","genre_gemma":"commentary","genre_scores_codex":[0.0002120415,0.008038753,0.0005925688,0.2951196,0.6823423,0.0008354174,0.002124813,0.0005855435,0.01014901],"genre_scores_gemma":[0.00433127,0.01065052,0.00124962,0.4549415,0.4380893,0.00273851,0.002209448,0.0007426254,0.08504711],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.9774448,"threshold_uncertainty_score":0.4121821,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07022534875474991,"score_gpt":0.3462041995318811,"score_spread":0.2759788507771312,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}