{"id":"W4377939098","doi":"10.1111/his.14938","title":"Genomic profiling of dedifferentiated endometrial carcinomas arising in the background of high‐grade carcinoma: a targeted next‐generation sequencing study","year":2023,"lang":"en","type":"article","venue":"Histopathology","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Genomics; Sunnybrook Hospital; University of Toronto; Sunnybrook Health Science Centre","funders":"Brigham and Women's Hospital","keywords":"ARID1A; MSH6; Immunohistochemistry; MSH2; MLH1; SMARCA4; Medicine; Endometrial cancer; SMARCB1; Malignancy; Oncology; Carcinoma; Targeted therapy; Microsatellite instability; Internal medicine; Pathology; Biology; Cancer research; Mutation; Epigenetics; Genetics; Cancer; DNA mismatch repair; Gene; Colorectal cancer; Microsatellite; Chromatin remodeling","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006280183,0.0001337687,0.0002829462,0.0002122641,0.00006337658,0.000008272513,0.0001951662,0.0001246966,0.000004809615],"category_scores_gemma":[0.00007002216,0.0001145092,0.000076964,0.0003796327,0.00007835469,0.000004036593,0.00007279788,0.0001159555,0.000001356747],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000757937,"about_ca_system_score_gemma":0.0001472376,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007088399,"about_ca_topic_score_gemma":0.0002919921,"domain_scores_codex":[0.9985161,0.0003472278,0.000461673,0.0003198425,0.000141552,0.000213547],"domain_scores_gemma":[0.9993317,0.00003657517,0.0002014789,0.0003385223,0.00007178171,0.0000199766],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000579755,0.00008637121,0.03009207,0.00002872781,0.000007107471,0.00001967922,0.0008862291,0.001148558,0.9674954,0.00004271506,0.00003126442,0.0001038511],"study_design_scores_gemma":[0.004545432,0.001298877,0.4429467,0.00002051901,0.0001333276,0.00007405112,0.007554103,0.009755326,0.5331627,0.0001364928,0.00002890537,0.0003435488],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978587,0.0009050873,0.0004401015,0.00001476888,0.0003799652,0.0003469377,0.0000140062,0.00001145466,0.00002898104],"genre_scores_gemma":[0.9990688,0.00002683982,0.000395708,0.0000186635,0.0002035894,0.00003570466,0.0002139129,0.00001858745,0.00001819174],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4343328,"threshold_uncertainty_score":0.466955,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08693820386755827,"score_gpt":0.2866985434590354,"score_spread":0.1997603395914772,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}