{"id":"W4377939098","doi":"10.1111/his.14938","title":"Genomic profiling of dedifferentiated endometrial carcinomas arising in the background of high‐grade carcinoma: a targeted next‐generation sequencing study","year":2023,"lang":"en","type":"article","venue":"Histopathology","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Genomics; Sunnybrook Hospital; University of Toronto; Sunnybrook Health Science Centre","funders":"Brigham and Women's Hospital","keywords":"ARID1A; MSH6; Immunohistochemistry; MSH2; MLH1; SMARCA4; Medicine; Endometrial cancer; SMARCB1; Malignancy; Oncology; Carcinoma; Targeted therapy; Microsatellite instability; Internal medicine; Pathology; Biology; Cancer research; Mutation; Epigenetics; Genetics; Cancer; DNA mismatch repair; Gene; Colorectal cancer; Microsatellite; Chromatin remodeling","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002428679,0.0001927572,0.000227917,0.0005914868,0.0001917642,0.000387918,0.0001618722,0.0003951892,0.0004951771],"category_scores_gemma":[0.0005784108,0.0001443526,0.0002418417,0.0003640692,0.000113921,0.00008753454,0.0002424156,0.0002022006,0.0001551916],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001620864,"about_ca_system_score_gemma":0.000126169,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006711221,"about_ca_topic_score_gemma":0.001316301,"domain_scores_codex":[0.9998349,0.00002190129,0.0000145817,0.00005665106,0.00004424014,0.00002780269],"domain_scores_gemma":[0.9997742,0.00006310181,0.00005251639,0.00002481543,0.00005274798,0.00003262132],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000942891,0.00009664637,0.2977642,0.0002412888,0.0002935324,0.005352951,0.0005144364,0.001022077,0.6610723,0.0002048645,0.0003729084,0.03212192],"study_design_scores_gemma":[0.00003841013,0.0004880278,0.9000615,0.0000574404,0.0003971253,0.01802711,0.0005160673,0.007488172,0.06793542,0.0002482612,0.00471859,0.00002385234],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972843,0.0005005855,0.001262189,0.0000334938,0.000004333711,0.00001321645,0.0005559776,0.00001865141,0.0003274347],"genre_scores_gemma":[0.9943379,0.0003596261,0.003324789,0.00009419696,0.000006395059,0.00001618688,0.001534448,0.00001161279,0.0003149787],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006711221,"threshold_uncertainty_score":0.001656473,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08693820386755827,"score_gpt":0.2866985434590354,"score_spread":0.1997603395914772,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}