{"id":"W4377942915","doi":"10.3389/fcvm.2023.1130162","title":"Lipoprotein(a) induces caspase-1 activation and IL-1 signaling in human macrophages","year":2023,"lang":"en","type":"article","venue":"Frontiers in Cardiovascular Medicine","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Sigrid Juséliuksen Säätiö; Sydäntutkimussäätiö; Novo Nordisk; Novo Nordisk Fonden; Academy of Finland; Aarne Koskelon Säätiö; Jenny ja Antti Wihurin Rahasto; Foundation for Cardiovascular Research; Heart and Stroke Foundation of Canada","keywords":"Cell biology; Signal transduction; Macrophage; Cancer research; Chemistry; Immunology; Medicine; Biology; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002348923,0.0003361981,0.0002406103,0.0002500842,0.0001632312,0.0003588793,0.0001041807,0.0003051472,0.002006616],"category_scores_gemma":[0.0001557851,0.0001265768,0.0004522344,0.0002195553,0.0001983451,0.0001660272,0.0002844848,0.0004996529,0.0008211762],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001826787,"about_ca_system_score_gemma":0.0002033215,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000209976,"about_ca_topic_score_gemma":0.0001865852,"domain_scores_codex":[0.9997839,0.00004294344,0.0000300582,0.00004731805,0.00004113875,0.00005469879],"domain_scores_gemma":[0.9999115,0.0000191621,0.00001791319,0.00001561688,0.00002108667,0.00001471815],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007419905,0.000120405,0.0004533969,0.0001185507,0.00001440678,0.0001164833,0.00005299804,0.00004316224,0.9959279,0.00004783346,0.0001399016,0.002222935],"study_design_scores_gemma":[0.0003351234,0.002355526,0.02106576,0.00004373304,0.00006755127,0.001105187,0.0002162451,0.001151402,0.9676376,0.0002823188,0.005722689,0.00001687032],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914641,0.003640709,0.002315949,0.0002386516,0.00008391141,0.00006868488,0.0007030598,0.00007117423,0.001413804],"genre_scores_gemma":[0.9916797,0.001720821,0.002438711,0.0002703527,0.00006902443,0.0001554303,0.00142617,0.00001322634,0.002226542],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002006616,"threshold_uncertainty_score":0.006712794,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02060501006048089,"score_gpt":0.2708296987857799,"score_spread":0.2502246887252991,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}