{"id":"W4377965636","doi":"10.1101/2023.05.24.542059","title":"ESCRT-III-dependent adhesive and mechanical changes are triggered by a mechanism sensing paracellular diffusion barrier alteration in <i>Drosophila</i> epithelial cells","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; National Institute of Child Health and Human Development; Directorate for Biological Sciences; Fondation pour la Recherche Médicale; Agence Nationale de la Recherche","keywords":"Paracellular transport; Cell biology; Adherens junction; Transcellular; Septate junctions; Tight junction; ESCRT; Cell junction; Biology; Barrier function; Chemistry; Intracellular; Cadherin; Cell; Endosome; Biochemistry; Membrane","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006268993,0.000262556,0.0001874193,0.0001306574,0.000150036,0.0002981167,0.0002208659,0.000228866,0.0009234383],"category_scores_gemma":[0.00005387323,0.0001384297,0.000266438,0.00006445936,0.0001850145,0.0001853948,0.0002323184,0.0005936544,0.0002922347],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003684279,"about_ca_system_score_gemma":0.0001206752,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000854657,"about_ca_topic_score_gemma":0.0009236156,"domain_scores_codex":[0.9999119,0.000009028587,0.0000104123,0.0000213834,0.00002329046,0.00002410504],"domain_scores_gemma":[0.9998983,0.000006396294,0.00004279259,0.00001355895,0.00001181502,0.00002714061],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001886706,0.000002703911,0.0002173737,0.0000169657,0.000003069234,0.00003773173,0.000004157321,0.0000176882,0.9994288,0.00003833769,0.00001803992,0.0001962355],"study_design_scores_gemma":[0.000006413236,0.00006099455,0.0216011,0.000007759217,0.00001521193,0.0003153449,0.00004710427,0.0007999546,0.9752426,0.00004493036,0.00185271,0.000005847755],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960728,0.0009703044,0.001336233,0.00006298276,0.00001575813,0.0000120963,0.0004687997,0.00008058591,0.0009804715],"genre_scores_gemma":[0.9967496,0.0003148812,0.0008056362,0.00006594586,0.000003773352,0.0000162382,0.0005003231,0.00001982743,0.001523689],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009234383,"threshold_uncertainty_score":0.00308919,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01168026682852467,"score_gpt":0.2130241677915868,"score_spread":0.2013439009630621,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}