{"id":"W4377966457","doi":"10.1056/nejmoa2212728","title":"Upadacitinib Induction and Maintenance Therapy for Crohn’s Disease","year":2023,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":427,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"AbbVie","keywords":"Crohn's disease; Maintenance therapy; Induction therapy; Medicine; Disease; Internal medicine; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001706598,0.0003743346,0.001503471,0.0003354246,0.00038783,0.0004750412,0.0004630479,0.0006475507,0.003830753],"category_scores_gemma":[0.001269968,0.0002084299,0.0006169674,0.0004155324,0.0004470997,0.000402411,0.0004350726,0.001073104,0.0005675989],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005158249,"about_ca_system_score_gemma":0.0008093929,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001932898,"about_ca_topic_score_gemma":0.0006201755,"domain_scores_codex":[0.9991478,0.0003374882,0.0001127417,0.0001372627,0.0001180546,0.0001466274],"domain_scores_gemma":[0.9989355,0.0002034127,0.0002675845,0.0001229858,0.00003810983,0.0004323431],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6556132,0.01620188,0.02300723,0.001058914,0.0007638904,0.0002819458,0.0001626274,0.001363787,0.01810729,0.0003917661,0.003851402,0.279196],"study_design_scores_gemma":[0.405167,0.4577948,0.1101441,0.0003595995,0.001213906,0.001609828,0.00008326338,0.00153478,0.009208285,0.0004008999,0.01241951,0.00006407373],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9874386,0.006063865,0.0005366503,0.000335808,0.00008841107,0.001942389,0.0004718285,0.00006399699,0.003058535],"genre_scores_gemma":[0.9927429,0.001540898,0.0012761,0.0004419536,0.000156067,0.002056631,0.0007991909,0.000008929879,0.0009772365],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003830753,"threshold_uncertainty_score":0.01281518,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01705111419669648,"score_gpt":0.2766292784025505,"score_spread":0.259578164205854,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}