{"id":"W4377966457","doi":"10.1056/nejmoa2212728","title":"Upadacitinib Induction and Maintenance Therapy for Crohn’s Disease","year":2023,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":427,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"AbbVie","keywords":"Crohn's disease; Maintenance therapy; Induction therapy; Medicine; Disease; Internal medicine; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004388662,0.00007979118,0.0001096987,0.00006212841,0.00004069069,0.000006255973,0.00006744438,0.00003626021,0.00001571764],"category_scores_gemma":[0.0003952194,0.00005422598,0.0000423591,0.00004671542,0.00006648828,0.00000514891,0.00001246836,0.00006155192,9.366067e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005608802,"about_ca_system_score_gemma":0.0001083629,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002310244,"about_ca_topic_score_gemma":0.000003772558,"domain_scores_codex":[0.9994288,0.00003385944,0.0001940411,0.0000992855,0.0001203853,0.0001236223],"domain_scores_gemma":[0.9994078,0.00002299615,0.0001213511,0.00009444452,0.0001240019,0.000229361],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.02400985,0.00007942828,0.03218531,0.0001469771,0.0002762444,0.001504552,0.0007684641,0.000170068,0.1705893,0.0005992467,0.2777284,0.4919422],"study_design_scores_gemma":[0.04317998,0.0007807466,0.6712252,0.0001280459,0.00005841306,0.000158938,0.0001686042,0.00007193649,0.001176233,0.00240348,0.2804992,0.0001492523],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945186,0.0008473442,0.0007319977,0.003274242,0.0004179991,0.0001297506,0.000008242446,0.000005672703,0.00006614697],"genre_scores_gemma":[0.992496,0.001621576,0.0001231415,0.0005127075,0.004399572,0.000004359931,0.00002632949,0.0000138818,0.0008024983],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6390399,"threshold_uncertainty_score":0.2211272,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01705111419669648,"score_gpt":0.2766292784025505,"score_spread":0.259578164205854,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}