{"id":"W4377969010","doi":"10.1016/j.bbrc.2023.05.096","title":"Epitope specific antibodies to N- and C cytoplasmic domains of the Plasmodium falciparum chloroquine resistance transporter (PfCRT) differentiate native and post-translationally modified variant","year":2023,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"Malaria Research and Control","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; King Abdulaziz University","keywords":"Epitope; Plasmodium falciparum; Antiserum; Molecular biology; Biology; Western blot; Antibody; Molecular mass; Monoclonal antibody; Biochemistry; Virology; Gene; Enzyme; Malaria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002329939,0.000432243,0.0001601666,0.0001958647,0.0001901833,0.0002785932,0.0002947109,0.0004806098,0.003188964],"category_scores_gemma":[0.0002774148,0.0002413375,0.0002825815,0.0001274629,0.0003000892,0.0002642419,0.0002239222,0.00082329,0.0007196729],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004329083,"about_ca_system_score_gemma":0.0002368183,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001265829,"about_ca_topic_score_gemma":0.002096153,"domain_scores_codex":[0.999778,0.0000289973,0.00001529269,0.00006508482,0.00002990402,0.00008274674],"domain_scores_gemma":[0.9997341,0.00007991588,0.00005634256,0.00003463011,0.0000460389,0.00004895317],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006731748,0.0000162577,0.0001126999,0.0000159415,0.000002768296,0.00001929593,0.00001054562,0.00002023612,0.9990783,0.0001379013,0.00004855457,0.0004702733],"study_design_scores_gemma":[0.00003996063,0.0002614216,0.007161228,0.00001155666,0.00002244868,0.0007549689,0.00004537029,0.001371392,0.9863998,0.0001514348,0.003772261,0.000008235819],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.983303,0.0005671045,0.01133358,0.0001547463,0.00005735696,0.00004360102,0.0002640895,0.0001030116,0.004173624],"genre_scores_gemma":[0.9860736,0.0005708275,0.007330011,0.0002274748,0.00002463141,0.00005307853,0.0007608976,0.00007159648,0.004887781],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003188964,"threshold_uncertainty_score":0.01066816,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05233297442651223,"score_gpt":0.33444359580486,"score_spread":0.2821106213783477,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}