{"id":"W4377986943","doi":"10.22541/au.168491344.40528968/v1","title":"Successful reversal of transgene silencing in Chlamydomonas reinhardtii","year":2023,"lang":"en","type":"preprint","venue":"","topic":"Algal biology and biofuel production","field":"Energy","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Trois-Rivières","funders":"Natural Sciences and Engineering Research Council of Canada; Mitacs; Canada Research Chairs; Université du Québec à Trois-Rivières","keywords":"Chlamydomonas reinhardtii; Biology; Transgene; Gene silencing; Histone deacetylase inhibitor; Cell cycle; Vorinostat; Epigenetics; Molecular biology; Histone deacetylase; Gene expression; Cell biology; Gene; Genetics; Histone","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005029963,0.0005572495,0.0005066864,0.0002508484,0.0002925444,0.0004263432,0.0004484539,0.0003853255,0.0004820737],"category_scores_gemma":[0.0002831352,0.000241418,0.0004621796,0.0002421077,0.0003096333,0.0001977103,0.0005774469,0.0009504596,0.000399961],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005378498,"about_ca_system_score_gemma":0.000461059,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00303395,"about_ca_topic_score_gemma":0.003589313,"domain_scores_codex":[0.9995638,0.00004505575,0.0000571495,0.000123283,0.0001088964,0.0001018353],"domain_scores_gemma":[0.9996958,0.000060118,0.00007194325,0.00007807468,0.00004781766,0.00004627342],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001116485,0.000006074997,0.00008230079,0.00001579089,0.000003061752,0.00002777301,0.00001721506,0.00002966648,0.9991426,0.00004900827,0.00001638086,0.000598836],"study_design_scores_gemma":[0.000004140218,0.00008397145,0.002605727,0.000005775835,0.00001264466,0.00009797157,0.00002895673,0.0005983756,0.9939255,0.00003628975,0.002592942,0.000007596117],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9798197,0.001517478,0.01422993,0.0002070124,0.00008971799,0.0001099892,0.001528773,0.00048909,0.002008333],"genre_scores_gemma":[0.9814218,0.0009045311,0.009537936,0.0000904247,0.000007990502,0.00008823958,0.001587921,0.0001948546,0.006166361],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00303395,"threshold_uncertainty_score":0.006032526,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03884294278802949,"score_gpt":0.2733517984023698,"score_spread":0.2345088556143403,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}