{"id":"W4378072467","doi":"10.3389/fped.2023.1183295","title":"A phase 1, first-in-child, multicenter study to evaluate the safety and efficacy of the oncolytic herpes virus talimogene laherparepvec in pediatric patients with advanced solid tumors","year":2023,"lang":"en","type":"article","venue":"Frontiers in Pediatrics","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine","funders":"Amgen","keywords":"Medicine; Oncolytic virus; Virology; Oncology; Internal medicine; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008571764,0.000223246,0.0003016053,0.0003197273,0.00009790617,0.00001710042,0.0004620579,0.00007253327,0.000002722754],"category_scores_gemma":[0.000337148,0.0001497183,0.00005638402,0.001561436,0.00007414142,0.000008754452,0.0003017233,0.0002023298,0.000002639772],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008902442,"about_ca_system_score_gemma":0.0001411961,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004335288,"about_ca_topic_score_gemma":0.00210126,"domain_scores_codex":[0.9978247,0.000318469,0.0004685416,0.0004842285,0.0004522208,0.0004518409],"domain_scores_gemma":[0.9990902,0.00007542896,0.0001148541,0.0005452646,0.00008889563,0.00008534692],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.009451012,0.002289053,0.9681901,0.00004400188,0.00003269848,0.00001615005,0.001591441,0.01191183,0.0001982877,1.293152e-7,0.0003944264,0.005880911],"study_design_scores_gemma":[0.02799021,0.006467383,0.9600021,0.00003175373,0.00008667869,4.989441e-7,0.001269277,0.001188907,0.002224608,0.000008419494,0.0003378675,0.0003923065],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965044,0.0009051111,0.00003138403,0.0001331015,0.0002212091,0.002119963,0.00005831641,0.000007899317,0.00001863614],"genre_scores_gemma":[0.9984696,0.001067247,0.00008842002,0.00008255838,0.00009955702,0.0001005054,0.00002385767,0.00003900505,0.0000292302],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0185392,"threshold_uncertainty_score":0.6105334,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00819633092713597,"score_gpt":0.2928972133231248,"score_spread":0.2847008823959888,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}