{"id":"W4378084823","doi":"10.3389/fendo.2023.1160936","title":"Efficacy and Safety of intravenous monoclonal antibodies in patients with moderate-to-severe active Graves’ophthalmopathy: a systematic review and meta-analysis","year":2023,"lang":"en","type":"review","venue":"Frontiers in Endocrinology","topic":"Ophthalmology and Eye Disorders","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"West China Hospital, Sichuan University; Sichuan University; Department of Science and Technology of Sichuan Province; National Natural Science Foundation of China","keywords":"Medicine; Tocilizumab; Meta-analysis; Cochrane Library; Rituximab; Adverse effect; Internal medicine; Diplopia; Graves' ophthalmopathy; Randomized controlled trial; MEDLINE; Relative risk; Surgery; Confidence interval; Graves' disease","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002678491,0.0006126937,0.01191856,0.001550299,0.00004621398,0.000006657197,0.0001940148,0.0002893936,0.00002231306],"category_scores_gemma":[0.0003090104,0.0004217351,0.0004992283,0.001280096,0.0002856967,0.0000530352,0.0001507585,0.0006155457,0.000004916338],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001014504,"about_ca_system_score_gemma":0.0001294678,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005754473,"about_ca_topic_score_gemma":0.00001883629,"domain_scores_codex":[0.9964648,0.000654488,0.001324201,0.0008053426,0.0002102653,0.0005408287],"domain_scores_gemma":[0.998394,0.0002842667,0.000564726,0.0005347017,0.0001057735,0.0001165942],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.001209816,0.0004705029,0.01045365,0.8219978,0.1601434,0.000785763,0.0005172747,0.00002488392,7.815136e-9,0.00006433986,0.00004876263,0.004283874],"study_design_scores_gemma":[0.00343386,0.001185882,0.02009932,0.04463061,0.9284287,0.0006986595,0.0003238622,0.00001140259,1.91813e-7,0.000144478,0.0002411892,0.0008018345],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003161864,0.9912015,0.00002907678,0.00007844609,0.0000641626,0.005148972,0.0001985189,0.00001861462,0.00009887581],"genre_scores_gemma":[0.003747156,0.994496,0.0007193547,0.00007852675,0.000004854747,0.0004838043,0.0002506138,0.00005586716,0.0001637851],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.7773672,"threshold_uncertainty_score":0.9998235,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04078235063857316,"score_gpt":0.323763282354416,"score_spread":0.2829809317158429,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}