{"id":"W4378085657","doi":"10.3390/cells12111453","title":"Generation of Chimeric Antigen Receptors against Tetraspanin 7","year":2023,"lang":"en","type":"article","venue":"Cells","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"Deutsche Forschungsgemeinschaft; European Commission; Government of Canada","keywords":"Chimeric antigen receptor; Tetraspanin; Antigen; Adoptive cell transfer; Receptor; Biology; Immunology; Cell biology; Antibody; Computational biology; T cell; Immune system; Cell; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002211552,0.000277717,0.0002197136,0.0002789736,0.00009827899,0.0002733175,0.0002560365,0.0004374253,0.0007031833],"category_scores_gemma":[0.0001860838,0.0001394394,0.0002867991,0.0001497336,0.0001723372,0.0002020726,0.0003075428,0.0006268868,0.0003232848],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002913162,"about_ca_system_score_gemma":0.0001821794,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002472755,"about_ca_topic_score_gemma":0.0002310894,"domain_scores_codex":[0.999837,0.00003305004,0.00001293929,0.00002671499,0.0000469156,0.00004317339],"domain_scores_gemma":[0.9999157,0.00001949584,0.00001892099,0.00001273846,0.00001797361,0.00001507816],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004432073,0.00002116371,0.0000899243,0.00002162776,0.000006641655,0.00004612632,0.00001477964,0.0002593607,0.9972376,0.0003680732,0.00006052561,0.001829796],"study_design_scores_gemma":[0.00003035717,0.0003941905,0.0006637612,0.000006135278,0.00002876479,0.0003032885,0.0000178349,0.004083535,0.9889591,0.00009447878,0.005411234,0.00000744155],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9759296,0.0009362808,0.02080405,0.000127581,0.00005845018,0.00009156824,0.0002178134,0.0001531413,0.001681483],"genre_scores_gemma":[0.9844393,0.0007710304,0.01199344,0.00008658497,0.00001341964,0.00007134208,0.0006610233,0.00003688824,0.001927043],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007031833,"threshold_uncertainty_score":0.002352417,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03230572874615237,"score_gpt":0.2449303582964544,"score_spread":0.212624629550302,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}