{"id":"W4378085657","doi":"10.3390/cells12111453","title":"Generation of Chimeric Antigen Receptors against Tetraspanin 7","year":2023,"lang":"en","type":"article","venue":"Cells","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"Deutsche Forschungsgemeinschaft; European Commission; Government of Canada","keywords":"Chimeric antigen receptor; Tetraspanin; Antigen; Adoptive cell transfer; Receptor; Biology; Immunology; Cell biology; Antibody; Computational biology; T cell; Immune system; Cell; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.000109602,0.00007645681,0.0001164167,0.0001312948,0.00007680123,0.000005113705,0.00006849434,0.0001047747,0.001841969],"category_scores_gemma":[0.00002104514,0.00007175621,0.00006163333,0.0002437928,0.00004717733,0.00007990883,0.00002081351,0.0001063931,0.005747439],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001499387,"about_ca_system_score_gemma":0.00001672945,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002014291,"about_ca_topic_score_gemma":0.000001669178,"domain_scores_codex":[0.999442,0.00007009625,0.0001916985,0.0001331906,0.00001958304,0.0001434273],"domain_scores_gemma":[0.9997004,0.00003033812,0.00008360597,0.0001372152,0.00004075942,0.000007625856],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001208281,0.00002379021,0.0001844228,0.000004706258,0.00003028467,3.131363e-7,0.000161249,0.00004881623,0.8540539,0.0000286494,0.1407877,0.004664063],"study_design_scores_gemma":[0.0001806789,0.00005042346,0.001035062,0.000006727993,0.000004941664,0.000001289355,0.0001494447,0.00005978868,0.7692997,0.000002507359,0.2291495,0.0000598913],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9805812,0.00039991,0.0001586664,0.0000605969,0.01113481,0.0001063697,0.000002539007,0.0001151623,0.007440751],"genre_scores_gemma":[0.9514652,0.0006066178,0.00002151647,0.0001028892,0.00005543287,0.000005167025,0.000381144,0.00001190446,0.04735014],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08836182,"threshold_uncertainty_score":0.9990705,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03230572874615237,"score_gpt":0.2449303582964544,"score_spread":0.212624629550302,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}