{"id":"W4378172182","doi":"10.1186/s12862-023-02129-7","title":"Synergistic inter-clonal cooperation involving crosstalk, co-option and co-dependency can enhance the invasiveness of genetically distant cancer clones","year":2023,"lang":"en","type":"article","venue":"BMC Ecology and Evolution","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of New Brunswick","funders":"New Brunswick Innovation Foundation; University of New Brunswick","keywords":"Biology; Autocrine signalling; Metastasis; Paracrine signalling; Phenotype; Crosstalk; Cancer research; Cancer; Cancer cell; clone (Java method); Genetic heterogeneity; Breast cancer; Somatic evolution in cancer; Cell culture; Genetics; Gene; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002664781,0.0003168293,0.0003155064,0.0002971831,0.0002953973,0.0005984942,0.0002918547,0.0003686192,0.001506628],"category_scores_gemma":[0.0003031002,0.0001571753,0.0003819751,0.0002061381,0.0002723685,0.0003330558,0.0006596121,0.0007059368,0.0003793003],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002212054,"about_ca_system_score_gemma":0.0002313685,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003121408,"about_ca_topic_score_gemma":0.001052407,"domain_scores_codex":[0.9995951,0.00008759443,0.00002050823,0.00006971273,0.0001337861,0.00009325046],"domain_scores_gemma":[0.999603,0.0001259886,0.00007355693,0.00006162334,0.00005409641,0.00008181677],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007510967,0.0000709016,0.001330352,0.00007306336,0.00001363506,0.0002272023,0.00007181794,0.0001636174,0.9939898,0.0003109287,0.0001111216,0.00356241],"study_design_scores_gemma":[0.00003792607,0.001075397,0.03346764,0.00004040421,0.0001287683,0.001874005,0.0003599738,0.008899027,0.9402599,0.0005195545,0.01330054,0.00003682612],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907131,0.00174908,0.00421988,0.0001318732,0.00003442014,0.00003663279,0.00007163329,0.00004403924,0.002999449],"genre_scores_gemma":[0.9952254,0.0004968236,0.002407143,0.00007215774,0.00001367436,0.00003911101,0.0001039624,0.000009894348,0.001631757],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001506628,"threshold_uncertainty_score":0.005040169,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01262658964102473,"score_gpt":0.2805100210286236,"score_spread":0.2678834313875988,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}