{"id":"W4378172367","doi":"10.1093/stcltm/szad022","title":"Reprogramming of Acute Myeloid Leukemia Patients Cells: Harboring Cancer Mutations Requires Targeting of AML Hierarchy","year":2023,"lang":"en","type":"article","venue":"Stem Cells Translational Medicine","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research; Canada Research Chairs","keywords":"Reprogramming; Myeloid leukemia; Induced pluripotent stem cell; Cancer research; Biology; Leukemia; Myeloid; CD33; Stem cell; CD34; Somatic cell; Immunology; Cell; Cell biology; Genetics; Embryonic stem cell; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004986257,0.0001772918,0.0002942786,0.0002167142,0.00009121543,0.000005093489,0.0002352902,0.0001179669,0.00005514421],"category_scores_gemma":[0.00002343277,0.0001624513,0.0001110951,0.0005212555,0.0002622914,0.00001244511,0.00005738859,0.0001321833,0.00000634128],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003145236,"about_ca_system_score_gemma":0.0002025548,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001258717,"about_ca_topic_score_gemma":0.00001332724,"domain_scores_codex":[0.9978131,0.00008869851,0.0006679267,0.0004109982,0.0006759002,0.0003433774],"domain_scores_gemma":[0.998928,0.0001039841,0.0002438238,0.0002591657,0.0003532743,0.0001117395],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000114451,0.00003679966,0.006886498,0.0002888963,0.0001930159,0.000005125967,0.0004509048,0.002470042,0.9818479,0.0000324935,0.0005242134,0.007149673],"study_design_scores_gemma":[0.001502021,0.000310888,0.005270069,0.000248201,0.00009942242,7.900539e-7,0.0001952566,0.001089007,0.9872178,0.00007600945,0.003805432,0.000185141],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959705,0.001101415,0.001038408,0.0003124894,0.0003668249,0.0004568102,0.0002304512,0.00002763143,0.0004954325],"genre_scores_gemma":[0.9966407,0.0009887605,0.0007267918,0.00001939632,0.0002092239,0.00004957429,0.0006759041,0.00003537888,0.0006542591],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006964532,"threshold_uncertainty_score":0.6624573,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0205530634738213,"score_gpt":0.2963707032215147,"score_spread":0.2758176397476934,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}