{"id":"W4378172971","doi":"10.14814/phy2.15696","title":"Inhibition of Wnt/β‐catenin signaling upregulates Na<sub>v</sub>1.5 channels in Brugada syndrome <scp>iPSC</scp>‐derived cardiomyocytes","year":2023,"lang":"en","type":"article","venue":"Physiological Reports","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Heart and Stroke Foundation of Canada; National Heart, Lung, and Blood Institute; National Institutes of Health; Stanford Cardiovascular Institute, School of Medicine, Stanford University; Canadian Institutes of Health Research; University of Ottawa","keywords":"Wnt signaling pathway; Gene knockdown; Downregulation and upregulation; Induced pluripotent stem cell; Small hairpin RNA; Catenin; Cell biology; Chemistry; Signal transduction; Endocrinology; Internal medicine; Biology; Medicine; Embryonic stem cell; Apoptosis; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002006704,0.0003190268,0.0002984045,0.0002726691,0.0001393698,0.0003472971,0.0001396265,0.000329143,0.002030613],"category_scores_gemma":[0.0000967562,0.0002038901,0.0003614446,0.0001310705,0.000218838,0.000178078,0.0001814778,0.0008638333,0.0005770791],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002638436,"about_ca_system_score_gemma":0.0001700846,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000799144,"about_ca_topic_score_gemma":0.001164175,"domain_scores_codex":[0.9997445,0.00003166574,0.00004659851,0.00005101906,0.00007721639,0.00004903209],"domain_scores_gemma":[0.9998803,0.00003138938,0.00003187752,0.00001240616,0.000009332853,0.00003478114],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002715886,0.00001554055,0.0001087988,0.000015998,0.000003835633,0.00004421657,0.00000774678,0.00001742856,0.9993729,0.00003454019,0.00003406251,0.0003178615],"study_design_scores_gemma":[0.00002338795,0.0001904151,0.006078348,0.000005876026,0.00002290262,0.0002741238,0.00002695831,0.0009278415,0.9901972,0.00001824745,0.00223113,0.000003647161],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927318,0.001116306,0.002309492,0.0001904049,0.00006811729,0.00005982585,0.001027248,0.0001428718,0.002353848],"genre_scores_gemma":[0.9919274,0.0007188739,0.002002916,0.0001261487,0.00001690491,0.00006887996,0.001124059,0.00004141827,0.003973463],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002030613,"threshold_uncertainty_score":0.006793082,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01906377799144729,"score_gpt":0.2470452858539988,"score_spread":0.2279815078625516,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}