{"id":"W4378174769","doi":"10.3390/brainsci13060852","title":"Indoleamine 2,3-Dioxygenase as a Therapeutic Target for Alzheimer’s Disease and Geriatric Depression","year":2023,"lang":"en","type":"review","venue":"Brain Sciences","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"Krembil Foundation","keywords":"Indoleamine 2,3-dioxygenase; Neuroinflammation; Kynurenine; Kynurenine pathway; Multiple sclerosis; Dementia; Depression (economics); Medicine; Downregulation and upregulation; Alzheimer's disease; Central nervous system; Regulator; Disease; Microglia; Inflammation; Neuroscience; Immunology; Psychology; Internal medicine; Biology; Tryptophan","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007554483,0.0004709399,0.0008139628,0.0005149326,0.0006391105,0.0003115952,0.00096971,0.0001595611,0.00005693772],"category_scores_gemma":[0.002274987,0.0003258215,0.0003385513,0.001713934,0.0006810358,0.0002475686,0.0002605873,0.0001859733,0.000131977],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001776015,"about_ca_system_score_gemma":0.0005999173,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008145311,"about_ca_topic_score_gemma":0.000002710306,"domain_scores_codex":[0.9966471,0.000333994,0.0004693728,0.001365857,0.0005519578,0.000631716],"domain_scores_gemma":[0.9962066,0.002748779,0.0003347718,0.0003692483,0.0000205822,0.0003199583],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002268452,0.00006843572,0.000002786174,0.002497395,0.00002518733,0.00002882896,0.00006109368,0.000003115207,0.0001039396,0.001371775,0.002837978,0.9929768],"study_design_scores_gemma":[0.0003690835,0.0001714212,0.00004068613,0.00148852,0.0001217563,0.00002543282,0.00004084526,0.000154453,0.0001826749,0.005626316,0.991163,0.0006158412],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001795609,0.9962906,0.00005802371,0.000311289,0.0003914449,0.002026951,0.0001633023,0.0002051314,0.0003736626],"genre_scores_gemma":[0.0003206657,0.9967927,0.0001731093,0.000960139,0.0002192865,0.0005145113,0.00001564061,0.00006750209,0.0009364568],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9923609,"threshold_uncertainty_score":0.9999194,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1604126746007417,"score_gpt":0.3968096550026318,"score_spread":0.2363969804018901,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}