{"id":"W4378190268","doi":"10.1016/j.jogc.2023.03.025","title":"Estetrol (E4) has distinct pharmacokinetic properties and a unique pharmacological profile supported by a tissue-selective mode-of-action","year":2023,"lang":"en","type":"article","venue":"Journal of Obstetrics and Gynaecology Canada","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"","keywords":"Medicine; Pharmacokinetics; Pharmacology; Mode of action; Action (physics); Toxicology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001851419,0.0003880241,0.000364202,0.000350708,0.0001544663,0.0004712698,0.0003157016,0.0003647684,0.005879447],"category_scores_gemma":[0.0003773531,0.0002410608,0.0003091752,0.0001995542,0.000416822,0.0003122792,0.0002152293,0.0005078977,0.001094909],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003178329,"about_ca_system_score_gemma":0.0004522639,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001253085,"about_ca_topic_score_gemma":0.001445338,"domain_scores_codex":[0.9999092,0.00003586627,0.000006008288,0.00001358933,0.00001522319,0.00002017955],"domain_scores_gemma":[0.999835,0.00006769739,0.00003366017,0.00001477217,0.00001627792,0.00003251361],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01272672,0.0005098307,0.003732857,0.0005729644,0.0001814198,0.001711328,0.0001957794,0.001218844,0.9028094,0.004262741,0.001397123,0.07068087],"study_design_scores_gemma":[0.00213829,0.01993187,0.05561417,0.00008170484,0.0003259143,0.01271479,0.0005790595,0.00257083,0.8436955,0.001706122,0.06052405,0.0001178283],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9610116,0.01003859,0.006809401,0.0006941552,0.0001024894,0.0002089583,0.002126247,0.0002122282,0.01879622],"genre_scores_gemma":[0.9759204,0.006736499,0.002741259,0.0003296847,0.00007884595,0.00007950111,0.001281669,0.00006996311,0.01276209],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005879447,"threshold_uncertainty_score":0.01966864,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01850125833528444,"score_gpt":0.2608005538487577,"score_spread":0.2422992955134733,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}