{"id":"W4378193816","doi":"10.1200/go.22.00384","title":"<i>QPOLE</i>: A Quick, Simple, and Cheap Alternative for <i>POLE</i> Sequencing in Endometrial Cancer by Multiplex Genotyping Quantitative Polymerase Chain Reaction","year":2023,"lang":"en","type":"article","venue":"JCO Global Oncology","topic":"Endometrial and Cervical Cancer Treatments","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver General Hospital; University of British Columbia; Surrey Memorial Hospital","funders":"Varian Medical Systems","keywords":"Genotyping; Multiplex; Multiplex polymerase chain reaction; Polymerase chain reaction; Endometrial cancer; Computational biology; Biology; Genetics; Cancer; Genotype; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004266814,0.0002590012,0.000747511,0.0002835777,0.00009914855,0.00001573524,0.00008413727,0.000223193,0.00004410808],"category_scores_gemma":[0.00081128,0.000230251,0.0001261668,0.001556643,0.0001170662,0.0001228734,0.00007352791,0.000203513,0.00002630324],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002901172,"about_ca_system_score_gemma":0.0004881461,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02009379,"about_ca_topic_score_gemma":0.003774299,"domain_scores_codex":[0.9979439,0.0001554181,0.0004968054,0.000551878,0.0002472633,0.0006047545],"domain_scores_gemma":[0.9983596,0.0009225179,0.0002270951,0.0001354185,0.00011132,0.0002440005],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.05199748,0.001409575,0.076703,0.0007581596,0.002006196,0.0007301631,0.003729456,0.0002871703,0.3968783,0.005151166,0.01364665,0.4467027],"study_design_scores_gemma":[0.3804662,0.03867609,0.1077672,0.001316059,0.002342592,0.0004659869,0.01273829,0.02761766,0.0964659,0.01377116,0.3147849,0.003587934],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862278,0.003800705,0.0003828571,0.003451776,0.001076542,0.001988964,0.001006902,0.0001134936,0.001951021],"genre_scores_gemma":[0.9936576,0.001564474,0.0008136015,0.002309734,0.0005779911,0.0005513896,0.0002718157,0.0000313707,0.0002220381],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4431148,"threshold_uncertainty_score":0.9864315,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06850152217454071,"score_gpt":0.4017772004977124,"score_spread":0.3332756783231717,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}