{"id":"W4378194483","doi":"10.1007/978-3-031-26078-0_3","title":"New β-Lactam-β-Lactamase Inhibitor Combinations","year":2023,"lang":"en","type":"book-chapter","venue":"Emerging infectious diseases of the 21st century","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"St. Michael's Hospital","funders":"","keywords":"Cephalosporin; Meropenem; Ceftazidime/avibactam; Beta-Lactamase Inhibitors; Imipenem/cilastatin; Carbapenem; Avibactam; Medicine; Tazobactam; Lactam; Pharmacology; Imipenem; Antibiotics; Ceftazidime; Microbiology; Biology; Chemistry; Bacteria; Antibiotic resistance; Pseudomonas aeruginosa; Stereochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001646088,0.0005334579,0.0003968384,0.0005648515,0.0001584282,0.0008689123,0.0004774027,0.000410462,0.008993271],"category_scores_gemma":[0.0002525014,0.0001711985,0.0002550298,0.0004619888,0.0001757729,0.0009943945,0.0003363419,0.001392193,0.003053868],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000400141,"about_ca_system_score_gemma":0.0002078609,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002159469,"about_ca_topic_score_gemma":0.000908349,"domain_scores_codex":[0.9998902,0.00001743551,0.000006141382,0.00001521106,0.00005942349,0.00001145769],"domain_scores_gemma":[0.9999499,0.00002457119,0.000006740787,0.00000237608,0.000008465975,0.000007865498],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002769953,0.000226784,0.0001454164,0.001294537,0.00004071142,0.0005881856,0.0001219077,0.001056449,0.04275961,0.03582411,0.06644773,0.8512176],"study_design_scores_gemma":[0.00004217776,0.0002093147,0.0002458693,0.0002780453,0.00002516432,0.001560659,0.00002303405,0.0006608874,0.008011898,0.006060458,0.9828684,0.00001411259],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"other","genre_scores_codex":[0.008894098,0.7474979,0.01295688,0.002654439,0.003226463,0.00008169138,0.0003072789,0.0003342751,0.2240469],"genre_scores_gemma":[0.0677166,0.6528978,0.02267445,0.00500379,0.001575871,0.000193909,0.000618812,0.0001607133,0.249158],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.008993271,"threshold_uncertainty_score":0.0300855,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006505917571846274,"score_gpt":0.2266295644202289,"score_spread":0.2201236468483826,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}