{"id":"W4378194483","doi":"10.1007/978-3-031-26078-0_3","title":"New β-Lactam-β-Lactamase Inhibitor Combinations","year":2023,"lang":"en","type":"book-chapter","venue":"Emerging infectious diseases of the 21st century","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"St. Michael's Hospital","funders":"","keywords":"Cephalosporin; Meropenem; Ceftazidime/avibactam; Beta-Lactamase Inhibitors; Imipenem/cilastatin; Carbapenem; Avibactam; Medicine; Tazobactam; Lactam; Pharmacology; Imipenem; Antibiotics; Ceftazidime; Microbiology; Biology; Chemistry; Bacteria; Antibiotic resistance; Pseudomonas aeruginosa; Stereochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00007242225,0.0004076457,0.0003536572,0.0001176201,0.000189295,0.0000391518,0.0004742797,0.000333673,0.0002067478],"category_scores_gemma":[0.0001930936,0.0003585436,0.0005680802,0.00008264717,0.0001935749,0.000007053905,0.0004455252,0.0002429821,0.00007295897],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006773816,"about_ca_system_score_gemma":0.000319795,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000316512,"about_ca_topic_score_gemma":0.00004519503,"domain_scores_codex":[0.998392,0.00004202288,0.0004439755,0.0004864357,0.0003387409,0.0002968105],"domain_scores_gemma":[0.9981875,0.00003576247,0.0004936628,0.000964465,0.0001460783,0.0001724627],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007348337,0.001400368,0.07242666,0.002253768,0.005268867,0.00006292914,0.0003095905,0.0005153497,0.04216708,0.255987,0.5888931,0.02998049],"study_design_scores_gemma":[0.003205852,0.0004850261,0.02896165,0.001714271,0.001453943,0.00003259274,0.0001436605,0.00001122751,0.005668172,0.01483416,0.9413,0.002189467],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"other","genre_gemma":"empirical","genre_scores_codex":[0.1026111,0.01739714,0.000293957,0.001595918,0.0297996,0.00371319,0.003298196,0.0008355233,0.8404554],"genre_scores_gemma":[0.5794154,0.005372074,0.00004843879,0.0002087764,0.001682907,0.00001137246,0.0007810964,0.0002946007,0.4121853],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.4768043,"threshold_uncertainty_score":0.9998866,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006505917571846274,"score_gpt":0.2266295644202289,"score_spread":0.2201236468483826,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}