{"id":"W4378194556","doi":"10.1007/978-3-031-26078-0_10","title":"New Systemic Antifungal: Isavuconazole","year":2023,"lang":"en","type":"book-chapter","venue":"Emerging infectious diseases of the 21st century","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"St. Michael's Hospital","funders":"","keywords":"Posaconazole; Voriconazole; Itraconazole; Azole; Aspergillosis; Aspergillus fumigatus; Echinocandins; Medicine; Antifungal; Drug; Pharmacology; Biology; Immunology; Caspofungin; Dermatology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001491724,0.0004820572,0.0008880599,0.0001951406,0.0001872487,0.00002443618,0.0003231167,0.0003084087,0.0008958565],"category_scores_gemma":[0.0002319134,0.0003664761,0.0011166,0.0001458176,0.0001907638,0.00006791435,0.0002565091,0.0005560973,0.0003354709],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002454083,"about_ca_system_score_gemma":0.000588965,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000110215,"about_ca_topic_score_gemma":0.00004626667,"domain_scores_codex":[0.9975837,0.00004035081,0.0006673015,0.000568712,0.0007467,0.0003932356],"domain_scores_gemma":[0.9976039,0.0001250836,0.0004967144,0.001255536,0.0002107195,0.0003080623],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001167517,0.0006544419,0.5995201,0.01453891,0.004739846,0.0002834651,0.0007378826,0.0001654702,0.002434225,0.1653451,0.1658925,0.0445205],"study_design_scores_gemma":[0.009897684,0.00113309,0.395191,0.04225594,0.01533943,0.0005356078,0.00164754,0.0001008875,0.0008006695,0.02588443,0.5025248,0.004688966],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"other","genre_gemma":"empirical","genre_scores_codex":[0.02826663,0.04340352,0.00005612486,0.000648452,0.01115311,0.003131381,0.0009746436,0.001522846,0.9108433],"genre_scores_gemma":[0.5714142,0.006026933,0.000007559523,0.0002085742,0.0007837149,0.000008343663,0.0001021987,0.0001742846,0.4212742],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.5431476,"threshold_uncertainty_score":0.9998787,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01211429217030642,"score_gpt":0.2500974102929641,"score_spread":0.2379831181226577,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}