{"id":"W4378195026","doi":"10.1007/s40744-023-00552-2","title":"Benefits of Autoantibody Enrichment in Early Rheumatoid Arthritis: Analysis of Efficacy Outcomes in Four Pooled Abatacept Trials","year":2023,"lang":"en","type":"article","venue":"Rheumatology and Therapy","topic":"Rheumatoid Arthritis Research and Therapies","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Leeds Biomedical Research Centre; Department of Health and Social Care; National Institute for Health and Care Research; Bristol-Myers Squibb","keywords":"Abatacept; Medicine; Rheumatoid arthritis; Spear; Internal medicine; Population; Surgery; Rituximab","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001969256,0.0002475727,0.002649314,0.002146072,0.00004663313,0.00001353856,0.0001520764,0.0001996746,0.0001365143],"category_scores_gemma":[0.0006208697,0.0002005673,0.0003320447,0.001836896,0.0002425916,0.0001046478,0.0000532495,0.0002398112,0.00001193847],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000166335,"about_ca_system_score_gemma":0.00009658939,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007726969,"about_ca_topic_score_gemma":0.0003725416,"domain_scores_codex":[0.9968044,0.0005276695,0.001449767,0.0003787221,0.0003538379,0.0004856263],"domain_scores_gemma":[0.9975525,0.001526253,0.0003427959,0.0003696427,0.00008973954,0.0001190816],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001138228,0.0004588723,0.9517372,0.00003668016,0.002316535,0.0000342073,0.002198341,0.00008269073,0.001172633,0.003377834,0.00002441334,0.03742236],"study_design_scores_gemma":[0.0131369,0.0004646042,0.9831055,0.0005263939,0.00001511557,0.00002983475,0.0002954158,0.0002837148,0.001204471,0.0006889199,0.00009263589,0.0001565299],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9654475,0.03311111,0.000008400411,0.0005326063,0.00008281414,0.0006543195,0.00005697006,0.00005185781,0.00005442487],"genre_scores_gemma":[0.6909024,0.3089271,0.00004428937,0.00001887119,0.000001809977,0.00004192831,0.00003316301,0.00001538011,0.00001507836],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2758159,"threshold_uncertainty_score":0.8178896,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03526373920569899,"score_gpt":0.3311106943248482,"score_spread":0.2958469551191493,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}