{"id":"W4378212018","doi":"10.1038/s41589-023-01349-8","title":"Deep learning-guided discovery of an antibiotic targeting Acinetobacter baumannii","year":2023,"lang":"en","type":"article","venue":"Nature Chemical Biology","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":328,"is_retracted":false,"has_abstract":false,"ca_institutions":"Population Health Research Institute; McMaster University","funders":"","keywords":"Acinetobacter baumannii; In silico; Antibiotics; Pathogen; Computational biology; Microbiology; Biology; Human pathogen; Mechanism (biology); Bacteria; Pseudomonas aeruginosa; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000257413,0.0004662141,0.0005733452,0.0003250929,0.0002012989,0.0006834004,0.000346262,0.0004797338,0.0009202106],"category_scores_gemma":[0.0005010049,0.0001638676,0.0003931089,0.0002730654,0.0001952131,0.0003164677,0.0004346264,0.0007606187,0.0002332326],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000666026,"about_ca_system_score_gemma":0.0008026463,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002457635,"about_ca_topic_score_gemma":0.005131106,"domain_scores_codex":[0.999878,0.0000182257,0.00000434875,0.00002209529,0.00004205829,0.00003520978],"domain_scores_gemma":[0.999886,0.00003404569,0.00002142314,0.000006389375,0.00002864237,0.0000235012],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008559127,0.0008011871,0.006605458,0.0007667948,0.0001888894,0.0004713472,0.0000585679,0.187521,0.5562901,0.007992506,0.007293058,0.2311551],"study_design_scores_gemma":[0.0001060541,0.001031031,0.001452796,0.00004270751,0.0001482275,0.0002246048,0.0000513734,0.7879499,0.1947846,0.002890514,0.01128909,0.0000290216],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8867196,0.006977766,0.08498653,0.002859114,0.0003196615,0.0001800282,0.00120048,0.001684989,0.01507192],"genre_scores_gemma":[0.9653414,0.001481865,0.02922882,0.0003335694,0.0000282692,0.00003671108,0.0005382495,0.00003470823,0.002976445],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002457635,"threshold_uncertainty_score":0.004886627,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007211184491840448,"score_gpt":0.2761145429364888,"score_spread":0.2689033584446484,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}