{"id":"W4378212018","doi":"10.1038/s41589-023-01349-8","title":"Deep learning-guided discovery of an antibiotic targeting Acinetobacter baumannii","year":2023,"lang":"en","type":"article","venue":"Nature Chemical Biology","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":328,"is_retracted":false,"has_abstract":false,"ca_institutions":"Population Health Research Institute; McMaster University","funders":"","keywords":"Acinetobacter baumannii; In silico; Antibiotics; Pathogen; Computational biology; Microbiology; Biology; Human pathogen; Mechanism (biology); Bacteria; Pseudomonas aeruginosa; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002402661,0.0002290679,0.0003206841,0.0000674098,0.0000483992,0.00001835536,0.0003858836,0.001003298,0.00002547055],"category_scores_gemma":[0.0004638133,0.0001949136,0.000130544,0.0002307315,0.0002599268,0.00001077549,0.0002220955,0.0004628354,0.00002193634],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001510284,"about_ca_system_score_gemma":0.00003199241,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007756424,"about_ca_topic_score_gemma":0.000005304794,"domain_scores_codex":[0.9984948,0.0001097906,0.0003558178,0.0005112328,0.00009759726,0.0004307611],"domain_scores_gemma":[0.9992206,0.00004886972,0.0001694045,0.0003734673,0.000107574,0.00008012707],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001047371,0.00003944756,0.0481552,0.00003678356,0.00004689479,0.000004258797,0.00002107779,0.00001596868,0.9499351,0.0001141081,0.000929986,0.0005964049],"study_design_scores_gemma":[0.000433943,0.0002162032,0.01803647,0.00002149647,0.00001921063,0.00001352745,0.00009426272,0.000191877,0.9744409,0.0001271907,0.006122697,0.0002822189],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984096,0.0004420002,0.0001605335,0.00008765081,0.0003175098,0.00011705,0.00001965127,0.00005539663,0.000390638],"genre_scores_gemma":[0.9956759,0.0001764327,0.0008653525,0.0001549346,0.000466756,0.000001969213,0.00235459,0.00003612417,0.0002679113],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03011873,"threshold_uncertainty_score":0.7948344,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007211184491840448,"score_gpt":0.2761145429364888,"score_spread":0.2689033584446484,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}