{"id":"W4378212585","doi":"10.1016/j.cmi.2023.05.024","title":"Which trial do we need? Plasma metagenomic next-generation sequencing to diagnose infections in patients with haematological malignancies and febrile neutropenia: proposal for a randomized-controlled trial","year":2023,"lang":"en","type":"article","venue":"Clinical Microbiology and Infection","topic":"Neutropenia and Cancer Infections","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Centre for Disease Control; University of British Columbia","funders":"National Cancer Institute; National Institutes of Health","keywords":"Medicine; Febrile neutropenia; Neutropenia; Randomized controlled trial; Metagenomics; Intensive care medicine; MEDLINE; Internal medicine; Chemotherapy; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03984155,0.003027426,0.01239868,0.0007591079,0.001749102,0.00636824,0.002248379,0.01250353,0.009362062],"category_scores_gemma":[0.05323001,0.001442739,0.01277371,0.001178052,0.004434999,0.005829193,0.002042208,0.00841227,0.002028127],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002434435,"about_ca_system_score_gemma":0.004466571,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001505032,"about_ca_topic_score_gemma":0.001865966,"domain_scores_codex":[0.9741929,0.01804612,0.002581096,0.00272126,0.001326708,0.001132053],"domain_scores_gemma":[0.9753875,0.01403602,0.003860438,0.002247704,0.002130331,0.002338158],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"not_applicable","study_design_scores_codex":[0.9149277,0.003250404,0.003302082,0.01009241,0.02068115,0.0001017783,0.0001977822,0.0008121307,0.001323727,0.00215365,0.004393726,0.03876346],"study_design_scores_gemma":[0.949115,0.02735296,0.001713522,0.002169182,0.008672544,0.00005043572,0.0001225267,0.0009808105,0.0003388842,0.004679711,0.00471251,0.00009189027],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.3970642,0.1716117,0.05425001,0.1284741,0.08732095,0.1400342,0.006374474,0.001280648,0.01358982],"genre_scores_gemma":[0.7370849,0.01875088,0.05623576,0.08286745,0.01154043,0.08571881,0.002330644,0.000248062,0.005223126],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.03984155,"threshold_uncertainty_score":0.2107047,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05593559986352949,"score_gpt":0.3267559909427253,"score_spread":0.2708203910791959,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}