{"id":"W4378212723","doi":"10.1158/2767-9764.crc-23-0144","title":"Mitochondria Transfer from Mesenchymal Stem Cells Confers Chemoresistance to Glioblastoma Stem Cells through Metabolic Rewiring","year":2023,"lang":"en","type":"article","venue":"Cancer Research Communications","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"The Metabolomics Innovation Centre","funders":"Société d'Accélération du Transfert de Technologies; Région Occitanie Pyrénées-Méditerranée; Institut National Du Cancer; Fondation ARC pour la Recherche sur le Cancer; Ministère de l'Education Nationale, de l'Enseignement Superieur et de la Recherche; Ligue Contre le Cancer; Agence Nationale de la Recherche","keywords":"Stem cell; Mesenchymal stem cell; Glioblastoma; Cancer stem cell; Cell biology; Mitochondrion; Cancer research; Biology; Neural stem cell; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006281685,0.0002772904,0.0003899529,0.0001912109,0.0005876751,0.000132824,0.002058685,0.0002072365,0.00008563792],"category_scores_gemma":[0.00002763539,0.0002945793,0.0001966156,0.001198802,0.0004109627,0.00002652784,0.0008436582,0.0005491755,0.0002287321],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001012715,"about_ca_system_score_gemma":0.0005817046,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009958755,"about_ca_topic_score_gemma":0.003299153,"domain_scores_codex":[0.9968588,0.0005078004,0.0004207634,0.0007315681,0.0006226887,0.0008583452],"domain_scores_gemma":[0.9958814,0.000176259,0.00005268404,0.003012586,0.0005445036,0.0003325907],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001714901,0.00005409197,0.00002741154,0.00002714824,0.0001428406,0.000001247644,0.001151961,0.0001878816,0.9422373,0.0006576926,0.04859511,0.006745831],"study_design_scores_gemma":[0.0004104928,0.00004234383,0.0001290631,0.00004369114,0.00002487388,4.980963e-7,0.0007007314,0.00005318808,0.5009525,0.00005245792,0.4974003,0.000189869],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9420975,0.04525275,0.001056802,0.004209547,0.001792498,0.001656025,0.001399625,0.0001576541,0.002377582],"genre_scores_gemma":[0.9214039,0.06374776,0.001041266,0.000493139,0.00147395,0.001712476,0.0001142842,0.0001305352,0.009882733],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4488052,"threshold_uncertainty_score":0.9999506,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08613808428419077,"score_gpt":0.37143782093573,"score_spread":0.2852997366515392,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}