{"id":"W4378231288","doi":"10.3390/cells12111461","title":"Impact of Short-Term (+)-JQ1 Exposure on Mouse Aorta: Unanticipated Inhibition of Smooth Muscle Contractility","year":2023,"lang":"en","type":"article","venue":"Cells","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Libin Cardiovascular Institute of Alberta; University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Contractility; Smooth muscle; Term (time); Aorta; Muscle contraction; Chemistry; Anatomy; Neuroscience; Medicine; Internal medicine; Biology; Physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003142027,0.0006005493,0.0005391599,0.0002668865,0.0002485437,0.0003784396,0.0004034296,0.0009710167,0.002404084],"category_scores_gemma":[0.000194056,0.0002967909,0.0004411913,0.0001446108,0.0004591536,0.0004747552,0.0002628293,0.001308069,0.0004393746],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002787184,"about_ca_system_score_gemma":0.0002874114,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007132055,"about_ca_topic_score_gemma":0.0009415729,"domain_scores_codex":[0.9997364,0.00003655521,0.00002721059,0.00006982632,0.00003348032,0.00009658315],"domain_scores_gemma":[0.9997019,0.00004972129,0.00006910059,0.00002815499,0.00002760108,0.0001234468],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005209033,0.00008912561,0.00008579875,0.00004350417,0.000006638597,0.0000427445,0.00001577022,0.00003474408,0.9986662,0.00004556121,0.00002989009,0.0004191743],"study_design_scores_gemma":[0.00008704935,0.001803981,0.004399959,0.00001152888,0.0000373367,0.0001300639,0.0000600882,0.0004408433,0.9918187,0.00005741908,0.001142469,0.00001053955],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966716,0.001281672,0.000612285,0.0002043353,0.00008736914,0.0000270177,0.0003509568,0.00005219802,0.0007126358],"genre_scores_gemma":[0.9932288,0.001273774,0.0009411258,0.0002106051,0.00004330438,0.0000745501,0.0004884489,0.00003144976,0.003707934],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002404084,"threshold_uncertainty_score":0.008042514,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02008076464524116,"score_gpt":0.2900859594119196,"score_spread":0.2700051947666784,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}