{"id":"W4378231868","doi":"10.3389/fmed.2023.1128557","title":"Prime editing strategies to mediate exon skipping in DMD gene","year":2023,"lang":"en","type":"article","venue":"Frontiers in Medicine","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Canadian Institutes of Health Research","keywords":"Exon; Tandem exon duplication; Frameshift mutation; Exon shuffling; Exon trapping; Exon skipping; Duchenne muscular dystrophy; Splice site mutation; Molecular biology; Genetics; Biology; splice; Gene; Mutation; RNA splicing; Alternative splicing; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000430369,0.0006042776,0.0004390081,0.0003058521,0.0002305949,0.0004135297,0.0004441765,0.0006608158,0.001489987],"category_scores_gemma":[0.0003791271,0.0003322148,0.0004246495,0.0001898779,0.0003354924,0.0002316334,0.0005533443,0.001248627,0.0007204778],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003201258,"about_ca_system_score_gemma":0.0002288324,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003080099,"about_ca_topic_score_gemma":0.0005591473,"domain_scores_codex":[0.9996007,0.00005871923,0.00004184724,0.0001288444,0.0001241365,0.00004571662],"domain_scores_gemma":[0.9998049,0.00005889438,0.00005419869,0.00003689747,0.00002227224,0.00002283565],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003940115,0.00002456512,0.00007988063,0.00009268304,0.00001168553,0.000199302,0.00005523374,0.0003521579,0.9924446,0.0009026555,0.0001415537,0.005656282],"study_design_scores_gemma":[0.00001430864,0.0001756762,0.0004416166,0.00001173137,0.00003053065,0.0007213282,0.00001494091,0.001651871,0.9820516,0.0002611665,0.01461101,0.00001420509],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5867036,0.0042937,0.3925163,0.0004437644,0.0003785267,0.0005916856,0.001335529,0.002375765,0.01136111],"genre_scores_gemma":[0.8647698,0.003140965,0.1170043,0.0002939828,0.00003880583,0.0004320613,0.001605091,0.0004340278,0.01228097],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001489987,"threshold_uncertainty_score":0.004984558,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008745567549923535,"score_gpt":0.3030129209092061,"score_spread":0.2942673533592826,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}