{"id":"W4378231868","doi":"10.3389/fmed.2023.1128557","title":"Prime editing strategies to mediate exon skipping in DMD gene","year":2023,"lang":"en","type":"article","venue":"Frontiers in Medicine","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Canadian Institutes of Health Research","keywords":"Exon; Tandem exon duplication; Frameshift mutation; Exon shuffling; Exon trapping; Exon skipping; Duchenne muscular dystrophy; Splice site mutation; Molecular biology; Genetics; Biology; splice; Gene; Mutation; RNA splicing; Alternative splicing; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004451774,0.0001328089,0.0002249238,0.000280736,0.00002162919,0.000007822512,0.0001556605,0.00009602655,0.000008059999],"category_scores_gemma":[0.000205189,0.0001291428,0.00002300646,0.0004335881,0.00003964167,0.000003774677,0.00007720089,0.0001174833,0.000006261018],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002560312,"about_ca_system_score_gemma":0.00003382193,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000424758,"about_ca_topic_score_gemma":0.00008157823,"domain_scores_codex":[0.9989414,0.00002569528,0.0002539041,0.0002868001,0.000148028,0.0003442066],"domain_scores_gemma":[0.9996564,0.000009690387,0.00002830205,0.0002010708,0.00002033412,0.0000841362],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005477917,0.00002096437,0.02822825,0.00008099413,0.00003849683,0.00009354557,0.00210344,0.01522708,0.8914358,0.00001863688,0.04271554,0.01998245],"study_design_scores_gemma":[0.006486026,0.001299907,0.2486561,0.001096354,0.00005958286,0.00003439355,0.0332682,0.01365808,0.5925384,0.001184355,0.1001971,0.001521587],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9137719,0.0023691,0.07935565,0.001072737,0.002118355,0.0002476268,0.000003819186,0.00004216368,0.001018663],"genre_scores_gemma":[0.9922811,0.0005929483,0.005370163,0.0002084948,0.00110489,0.00003612021,0.00009784997,0.00002677321,0.000281677],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2988974,"threshold_uncertainty_score":0.526629,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008745567549923535,"score_gpt":0.3030129209092061,"score_spread":0.2942673533592826,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}