{"id":"W4378232064","doi":"10.3389/fimmu.2023.1190810","title":"Short chain fatty acids prime colorectal cancer cells to activate antitumor immunity","year":2023,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; University of Alberta; Canadian Institutes of Health Research; Cancer Research Society","keywords":"Downregulation and upregulation; Immune system; CD8; Cancer research; Biology; Tumor microenvironment; Cell biology; Immunology; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002608287,0.0002054231,0.000318168,0.0001948288,0.0001236995,0.0000134927,0.0003812608,0.0003052995,0.00002102941],"category_scores_gemma":[0.00003815534,0.0002173073,0.00007539379,0.0004230526,0.0001437263,0.000005241723,0.0003143728,0.0002902267,0.00005534154],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001079913,"about_ca_system_score_gemma":0.0001751581,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002134252,"about_ca_topic_score_gemma":0.0001395679,"domain_scores_codex":[0.9984494,0.0001473234,0.0002626567,0.0004273928,0.00006508287,0.0006481148],"domain_scores_gemma":[0.9994476,0.00000872882,0.00004995237,0.0003698773,0.00004796252,0.00007590281],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003016021,0.00005127102,0.04157656,0.00001312685,0.00008202481,0.00001074408,0.0001921751,0.00004102212,0.9422097,0.000007875385,0.01060248,0.004911387],"study_design_scores_gemma":[0.0003942409,0.0002266668,0.2977998,0.0000158948,0.00000651695,0.000006289,0.0002557803,0.00002156401,0.6771147,0.0000179981,0.02392492,0.0002157166],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947746,0.0009227961,0.000838518,0.0004101539,0.002336572,0.0004055275,0.00006485054,0.00004608236,0.0002009442],"genre_scores_gemma":[0.9952832,0.001940066,0.001321862,0.0002821488,0.0001124834,0.0001018811,0.0001796999,0.00003637675,0.000742299],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2650951,"threshold_uncertainty_score":0.8861536,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009084087184464533,"score_gpt":0.2629143832560947,"score_spread":0.2538302960716302,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}