{"id":"W4378232064","doi":"10.3389/fimmu.2023.1190810","title":"Short chain fatty acids prime colorectal cancer cells to activate antitumor immunity","year":2023,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; University of Alberta; Canadian Institutes of Health Research; Cancer Research Society","keywords":"Downregulation and upregulation; Immune system; CD8; Cancer research; Biology; Tumor microenvironment; Cell biology; Immunology; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007021984,0.00027407,0.0001589637,0.0001940499,0.00007513176,0.0001968394,0.00005677305,0.0001938772,0.004247254],"category_scores_gemma":[0.00008210358,0.00006530944,0.0001761748,0.0001116632,0.0000922088,0.0001134337,0.0001714371,0.0003645963,0.0007776942],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001242598,"about_ca_system_score_gemma":0.00009704625,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00012761,"about_ca_topic_score_gemma":0.00025758,"domain_scores_codex":[0.999922,0.00001445732,0.000006371824,0.00001497691,0.00001864742,0.00002362125],"domain_scores_gemma":[0.9999201,0.00001539013,0.000017265,0.000008977969,0.00001517941,0.00002305868],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000224305,0.00003334458,0.0005050787,0.00009229598,0.000004896203,0.00004106122,0.00001294076,0.00004103339,0.994471,0.00005583431,0.00009267975,0.004425676],"study_design_scores_gemma":[0.00008703818,0.002812748,0.01724204,0.00004023137,0.00003668086,0.0006841733,0.00009602401,0.0006038877,0.963155,0.0001610614,0.01507258,0.000008577753],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875997,0.005533057,0.00185508,0.0001998498,0.0000891515,0.00005436697,0.0005699852,0.0001039258,0.003995004],"genre_scores_gemma":[0.9922308,0.001622795,0.001450875,0.000117145,0.00003819324,0.00003596295,0.0006460716,0.00001372466,0.00384442],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004247254,"threshold_uncertainty_score":0.01420844,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009084087184464533,"score_gpt":0.2629143832560947,"score_spread":0.2538302960716302,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}