{"id":"W4378232952","doi":"10.2147/dddt.s368584","title":"Profile of Luspatercept in the Treatment of Anemia in Adults with Non-Transfusion-Dependent β-Thalassemia (NTDT): Design, Development and Potential Place in Therapy","year":2023,"lang":"en","type":"review","venue":"Drug Design Development and Therapy","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Thalassemia; Medicine; Anemia; Transfusion therapy; Intensive care medicine; Blood transfusion; Pediatrics; Surgery; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007870875,0.0006111705,0.001510542,0.001723298,0.0001733558,0.0009145549,0.0008534624,0.0008153395,0.003528772],"category_scores_gemma":[0.0006696264,0.0002530989,0.0008443065,0.001460457,0.0002406206,0.0007770316,0.0003234081,0.001473348,0.001238716],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004433955,"about_ca_system_score_gemma":0.000745199,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008661593,"about_ca_topic_score_gemma":0.002429336,"domain_scores_codex":[0.9998165,0.00003955887,0.00003445303,0.00002724029,0.0000652844,0.00001699927],"domain_scores_gemma":[0.9997136,0.000135317,0.00006463357,0.000005564856,0.00005819976,0.00002280384],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003340873,0.0001007046,0.0001592101,0.03212282,0.0003044865,0.0002182244,0.00005538469,0.0004257921,0.002232579,0.001796852,0.01640546,0.9458444],"study_design_scores_gemma":[0.000338554,0.000811579,0.001696823,0.01327994,0.0009429333,0.002623917,0.00006862698,0.0003286501,0.00149095,0.001579152,0.9767993,0.00003958559],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002574152,0.9986874,0.00007265743,0.0001531086,0.00007166227,0.00001066516,0.00002630564,0.000005363877,0.0007152914],"genre_scores_gemma":[0.00139145,0.997575,0.0001925322,0.0002502093,0.00005497254,0.00001231346,0.00004864787,0.000001589594,0.000473299],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003528772,"threshold_uncertainty_score":0.01180494,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02885699474887819,"score_gpt":0.2702730167854807,"score_spread":0.2414160220366025,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}