{"id":"W4378347748","doi":"10.1038/s41389-023-00475-1","title":"CDK4/6 inhibitors and the pRB-E2F1 axis suppress PVR and PD-L1 expression in triple-negative breast cancer","year":2023,"lang":"en","type":"article","venue":"Oncogenesis","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"CIHR Skin Research Training Centre; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Cure Brain Cancer Foundation; Canadian Cancer Society; Government of Canada","keywords":"Triple-negative breast cancer; Cancer research; Breast cancer; Oncology; Medicine; Internal medicine; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009030149,0.0002742577,0.0003354354,0.0002238112,0.0001452607,0.0002570297,0.0001671731,0.0001612651,0.00158494],"category_scores_gemma":[0.00006809577,0.0001158555,0.0002200348,0.0001250026,0.000130168,0.0001490379,0.00009595654,0.0005355477,0.000397229],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000356156,"about_ca_system_score_gemma":0.0003389849,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007253247,"about_ca_topic_score_gemma":0.001679298,"domain_scores_codex":[0.9999485,0.000006014212,0.000004611177,0.000009825804,0.00001146662,0.00001951037],"domain_scores_gemma":[0.9999756,0.00000330489,0.0000061212,0.000003315484,0.000002879397,0.000008861821],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001363256,0.0003155409,0.0008409175,0.0001144583,0.00001835656,0.000100951,0.00001478222,0.0004228473,0.976932,0.0002627522,0.0008223504,0.01879177],"study_design_scores_gemma":[0.0003036011,0.001390558,0.009378585,0.000006907375,0.00003849099,0.000574072,0.00003290093,0.002968523,0.9754596,0.000149655,0.009689406,0.000007660327],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879035,0.005648096,0.001485282,0.0002654304,0.00006753963,0.00005023333,0.0005108905,0.0002530897,0.003815864],"genre_scores_gemma":[0.9941355,0.001432548,0.001167064,0.0001069475,0.00001229554,0.00005158858,0.0005197211,0.0000219922,0.00255239],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00158494,"threshold_uncertainty_score":0.005302191,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01299193462303701,"score_gpt":0.2912556387195237,"score_spread":0.2782637040964867,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}