{"id":"W4378349452","doi":"10.1002/pmic.202200372","title":"Hepatocyte nuclear factor 4α multiple isoforms, their functions, and their interactomes","year":2023,"lang":"en","type":"review","venue":"PROTEOMICS","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Canadian Institutes of Health Research","keywords":"Gene isoform; Alternative splicing; Transcription factor; Biology; Computational biology; Hepatocyte nuclear factors; Hepatocyte nuclear factor 4; Nuclear receptor; Genetics; RNA splicing; Gene; Cell biology; Function (biology); Regulation of gene expression; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001686594,0.0005367526,0.001741271,0.0002974657,0.0001408442,0.00008123169,0.0001285977,0.0003613476,0.0002158142],"category_scores_gemma":[0.000553912,0.0003218695,0.0004569775,0.0002833849,0.0000848022,0.0001053548,0.0001621793,0.0006137979,0.0007625985],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001582334,"about_ca_system_score_gemma":0.0001988139,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000024458,"about_ca_topic_score_gemma":0.000003236183,"domain_scores_codex":[0.9984097,0.00006822578,0.000571953,0.0004694222,0.0001278498,0.0003528123],"domain_scores_gemma":[0.9984921,0.0004352302,0.0002815443,0.0004911775,0.00007138382,0.0002285491],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008884113,0.00009609103,0.0005855807,0.0189735,0.0008675224,0.00000783633,0.00036311,6.196697e-8,0.0000677658,0.00003124131,0.002319353,0.9765991],"study_design_scores_gemma":[0.0005658829,0.0001386996,0.00006900096,0.007138162,0.0002849523,0.00006801457,0.0002570903,0.0002670909,0.00004411297,0.00004296395,0.9907938,0.0003301832],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.006072499,0.9884954,0.00007569595,0.0000820518,0.0006089194,0.002981622,0.0005154427,0.0004905496,0.0006777843],"genre_scores_gemma":[0.0002458004,0.9949368,0.0003748445,0.0001641564,0.0003571259,0.0003371598,0.0003252087,0.0001644198,0.003094455],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9884745,"threshold_uncertainty_score":0.9999233,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07761423197246997,"score_gpt":0.3086576760125064,"score_spread":0.2310434440400364,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}