{"id":"W4378349452","doi":"10.1002/pmic.202200372","title":"Hepatocyte nuclear factor 4α multiple isoforms, their functions, and their interactomes","year":2023,"lang":"en","type":"review","venue":"PROTEOMICS","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Canadian Institutes of Health Research","keywords":"Gene isoform; Alternative splicing; Transcription factor; Biology; Computational biology; Hepatocyte nuclear factors; Hepatocyte nuclear factor 4; Nuclear receptor; Genetics; RNA splicing; Gene; Cell biology; Function (biology); Regulation of gene expression; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003553495,0.0007144279,0.00113242,0.002133775,0.0001936375,0.0008514556,0.0005463082,0.0006381895,0.002373321],"category_scores_gemma":[0.0003290357,0.0002427061,0.000377277,0.001969767,0.0002987908,0.0008972863,0.0005120575,0.0010379,0.00193297],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005012995,"about_ca_system_score_gemma":0.0006160816,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008462194,"about_ca_topic_score_gemma":0.001152523,"domain_scores_codex":[0.9998596,0.00001935611,0.0000227303,0.00002762864,0.00005116356,0.00001947714],"domain_scores_gemma":[0.9998757,0.00004618267,0.00002374423,0.000003878003,0.00003649544,0.00001406603],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001323106,0.00004294364,0.0003633417,0.01413776,0.0001355126,0.0002853578,0.00005319664,0.0001830536,0.005716645,0.002289424,0.01291486,0.9637457],"study_design_scores_gemma":[0.00001530272,0.00008522897,0.002149789,0.001687309,0.0001850456,0.002595071,0.00005218227,0.00008606963,0.002007402,0.001227334,0.9898868,0.00002242269],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002225814,0.9987094,0.0001242116,0.000114295,0.00007675033,0.000002837295,0.0000263753,0.000006705186,0.0007168682],"genre_scores_gemma":[0.0009321527,0.997919,0.0001744518,0.0000929549,0.00009256152,0.000005754742,0.00006712021,0.000001451311,0.0007145597],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002373321,"threshold_uncertainty_score":0.007939517,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07761423197246997,"score_gpt":0.3086576760125064,"score_spread":0.2310434440400364,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}