{"id":"W4378349560","doi":"10.1002/oby.23774","title":"Pharmacological antagonism of receptor for advanced glycation end products signaling promotes thermogenesis, healthful body mass and composition, and metabolism in mice","year":2023,"lang":"en","type":"article","venue":"Obesity","topic":"Advanced Glycation End Products research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; U.S. Public Health Service; NYU Grossman School of Medicine; York University; American Heart Association","keywords":"Rage (emotion); Endocrinology; Internal medicine; Thermogenesis; Lean body mass; Lipolysis; Glycation; Adipose tissue; White adipose tissue; Thermogenin; Signal transduction; Receptor; Chemistry; Medicine; Biology; Biochemistry; Body weight; Neuroscience","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003854228,0.0009088512,0.0005109636,0.0007481007,0.0003003253,0.0005003366,0.0004184437,0.000581687,0.002004972],"category_scores_gemma":[0.0001373917,0.0003809057,0.0005769792,0.0003382562,0.0006438871,0.0003723898,0.0002559549,0.001475139,0.0006456911],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003995026,"about_ca_system_score_gemma":0.0003924705,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005000212,"about_ca_topic_score_gemma":0.001032898,"domain_scores_codex":[0.9996876,0.00004795427,0.00002977889,0.00007757365,0.00006684531,0.0000903386],"domain_scores_gemma":[0.9997895,0.00001625655,0.00007798822,0.00002094579,0.00001502683,0.00008036537],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009410582,0.0002967424,0.0001617318,0.00004094836,0.00001686136,0.00003704223,0.00001433125,0.00009982307,0.9967526,0.0001610281,0.0000871976,0.001390541],"study_design_scores_gemma":[0.0003844296,0.002998482,0.003606477,0.00002134746,0.00006059836,0.0002126747,0.00004470216,0.001386634,0.9886269,0.000152814,0.002491551,0.00001335337],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9873,0.00200804,0.006151839,0.0005176199,0.000138522,0.00009979798,0.001100485,0.0004055669,0.00227821],"genre_scores_gemma":[0.9805104,0.002827855,0.00768306,0.0003460083,0.00007353185,0.0003033977,0.001304239,0.0001324529,0.006819107],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002004972,"threshold_uncertainty_score":0.006707311,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01922976569401702,"score_gpt":0.3188097241171021,"score_spread":0.299579958423085,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}