{"id":"W4378387820","doi":"10.3389/fpain.2023.1190440","title":"Spinal cord vascular degeneration impairs duloxetine penetration","year":2023,"lang":"en","type":"article","venue":"Frontiers in Pain Research","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"European Foundation for the Study of Diabetes; Trent University; Nottingham Trent University","keywords":"Duloxetine; Spinal cord; Medicine; Nociception; Anesthesia; Pharmacology; Internal medicine; Receptor; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007172555,0.0001168018,0.0002095613,0.0007730118,0.0001663621,0.00003574361,0.0001017555,0.0001198847,0.00006604794],"category_scores_gemma":[0.0007599294,0.0001061188,0.00009366527,0.001296676,0.00005938752,0.00007361259,0.00004411591,0.0003220967,0.0001261029],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002819652,"about_ca_system_score_gemma":0.0001537395,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009755898,"about_ca_topic_score_gemma":0.00004313454,"domain_scores_codex":[0.9973333,0.0007448985,0.000224482,0.0003537486,0.0008118139,0.0005317096],"domain_scores_gemma":[0.9992706,0.00007651542,0.00002482499,0.0003196326,0.0001554787,0.0001529205],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002474451,0.0006928816,0.4141189,0.0004187232,0.0002994798,0.001288539,0.0004411393,0.0002444429,0.01466087,0.001060965,0.2855489,0.2787507],"study_design_scores_gemma":[0.01194439,0.01303197,0.6383801,0.0008332067,0.0001200026,0.00002808979,0.006218953,0.2603169,0.01304162,0.0157075,0.03959695,0.000780323],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9569598,0.001256597,0.03658228,0.001831279,0.0005284516,0.001404347,0.000005390539,0.000164548,0.0012673],"genre_scores_gemma":[0.9809059,0.0005270775,0.01481542,0.0001222652,0.000210722,0.0002234142,0.0002506455,0.00003280836,0.002911737],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2779703,"threshold_uncertainty_score":0.4327399,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08205480832424479,"score_gpt":0.3930944418720163,"score_spread":0.3110396335477715,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}