{"id":"W4378417578","doi":"10.1016/j.jaad.2023.05.041","title":"A case-control pharmacovigilance study of TNF-alpha inhibitors and interleukin inhibitors on tuberculosis, Candida, lymphoma and suicidality using the FAERS database (2014-2020)","year":2023,"lang":"en","type":"article","venue":"Journal of the American Academy of Dermatology","topic":"Pharmacovigilance and Adverse Drug Reactions","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; McGill University Health Centre","funders":"McGill University","keywords":"Medicine; Pharmacovigilance; Adverse Event Reporting System; Tuberculosis; Tumor necrosis factor alpha; Pharmacology; Immunology; Database; Adverse effect; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001502728,0.0005486405,0.00107832,0.002284876,0.0009944466,0.001553216,0.0007895837,0.001286964,0.002362468],"category_scores_gemma":[0.005058165,0.0008700162,0.002069632,0.00252383,0.000376908,0.0008224812,0.0008780299,0.001136809,0.0004055083],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001571379,"about_ca_system_score_gemma":0.001097598,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.03502133,"about_ca_topic_score_gemma":0.02726917,"domain_scores_codex":[0.9974841,0.0005460178,0.0004740539,0.0008647661,0.0003938832,0.0002371849],"domain_scores_gemma":[0.9975006,0.0005787897,0.0009104494,0.0003546223,0.0004052847,0.0002501839],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002473153,0.000461601,0.9891176,0.000148099,0.002201568,0.001353283,0.0001657024,0.00009771343,0.0006339274,0.0001078085,0.0009511156,0.002288622],"study_design_scores_gemma":[0.0005296575,0.0005646588,0.9941281,0.00005568012,0.001358527,0.001759697,0.0002443222,0.0004787882,0.0001636616,0.00005552253,0.0006293222,0.00003202742],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939235,0.001051459,0.0003216008,0.00007494832,0.00003301088,0.0001387675,0.003893748,0.00001209909,0.0005508174],"genre_scores_gemma":[0.9949762,0.0003449063,0.0004990414,0.0001393125,0.00002809388,0.00007501811,0.003583532,0.000005666199,0.0003482671],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03502133,"threshold_uncertainty_score":0.06963497,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06389973989305911,"score_gpt":0.4208996498155261,"score_spread":0.356999909922467,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}