{"id":"W4378417875","doi":"10.1016/j.bioorg.2023.106623","title":"Fangchinoline derivatives inhibits PI3K signaling in vitro and in vivo in non-small cell lung cancer","year":2023,"lang":"en","type":"article","venue":"Bioorganic Chemistry","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ministry of Agriculture","funders":"Major Scientific and Technological Innovation Project of Shandong Province; National Key Research and Development Program of China; Natural Science Foundation of Shandong Province; Shandong Academy of Agricultural Sciences; National Natural Science Foundation of China","keywords":"Chemistry; In vivo; A549 cell; Cell growth; PI3K/AKT/mTOR pathway; Apoptosis; Protein kinase B; IC50; Cell culture; Docking (animal); Cancer cell; Pharmacology; Cell; In vitro; Kinase; Biochemistry; Cancer; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001776244,0.0001706634,0.0002968289,0.0001057365,0.00002000332,0.00001305573,0.00007622979,0.0001605435,0.0001766375],"category_scores_gemma":[0.0001132383,0.0001496379,0.00002736038,0.0007420875,0.00003718658,0.00003576103,0.00009380542,0.000306666,0.000003334005],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001310936,"about_ca_system_score_gemma":0.00009522138,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002673029,"about_ca_topic_score_gemma":0.00009838695,"domain_scores_codex":[0.9989321,0.00001269571,0.0002854477,0.0003813595,0.00008775424,0.0003006518],"domain_scores_gemma":[0.9996639,0.00004718293,0.00005782863,0.0001409458,0.00002413981,0.00006599246],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001041827,0.00006363332,0.01133149,0.0006488084,0.000006719918,0.0000605981,0.0004216902,0.000002222582,0.9866871,7.44663e-8,0.0002583822,0.0004151035],"study_design_scores_gemma":[0.001124874,0.00000636724,0.007426132,0.0004556217,0.00001188391,0.000007294787,0.0002384016,0.0001930987,0.9902505,0.000003536639,0.0001134978,0.0001687583],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969747,0.001409805,4.056448e-7,0.001116752,0.00003159979,0.0002251691,0.00001930354,0.00003349913,0.0001887642],"genre_scores_gemma":[0.9982572,0.0004389275,0.00008683157,0.000141074,0.0001616987,0.000003412325,0.00001855726,0.00002349647,0.0008688336],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003905356,"threshold_uncertainty_score":0.6102057,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01045191668035349,"score_gpt":0.2356126653979197,"score_spread":0.2251607487175662,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}