{"id":"W4378417875","doi":"10.1016/j.bioorg.2023.106623","title":"Fangchinoline derivatives inhibits PI3K signaling in vitro and in vivo in non-small cell lung cancer","year":2023,"lang":"en","type":"article","venue":"Bioorganic Chemistry","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ministry of Agriculture","funders":"Major Scientific and Technological Innovation Project of Shandong Province; National Key Research and Development Program of China; Natural Science Foundation of Shandong Province; Shandong Academy of Agricultural Sciences; National Natural Science Foundation of China","keywords":"Chemistry; In vivo; A549 cell; Cell growth; PI3K/AKT/mTOR pathway; Apoptosis; Protein kinase B; IC50; Cell culture; Docking (animal); Cancer cell; Pharmacology; Cell; In vitro; Kinase; Biochemistry; Cancer; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007666027,0.0002154688,0.0001746787,0.0001781773,0.0001351504,0.0001297915,0.0001454309,0.0001839313,0.001672766],"category_scores_gemma":[0.00006157686,0.00007865459,0.0002360048,0.0001481501,0.0001048081,0.0001074719,0.000106409,0.0004673064,0.0001916929],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002232511,"about_ca_system_score_gemma":0.0002935914,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001644221,"about_ca_topic_score_gemma":0.003853502,"domain_scores_codex":[0.9999578,0.00000721783,0.000002574512,0.000005638245,0.00000700752,0.00001966899],"domain_scores_gemma":[0.9999748,0.00000583193,0.000003961302,0.000003717997,0.000003561368,0.000008072823],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00142093,0.0002642392,0.0004419013,0.000107964,0.00003384133,0.0001098414,0.0000301476,0.0003803217,0.9888564,0.0002087999,0.00037159,0.007774055],"study_design_scores_gemma":[0.0002770829,0.003976944,0.00622437,0.00001184778,0.00009209239,0.0002706232,0.00005945824,0.001000086,0.9825968,0.00009835079,0.005381044,0.00001123486],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953331,0.001564258,0.0006977629,0.00008065496,0.00003635043,0.00003390056,0.0003429404,0.00005571334,0.00185538],"genre_scores_gemma":[0.9960496,0.001025843,0.000327588,0.00003830738,0.000004209954,0.00002872202,0.0003993598,0.000007970968,0.002118585],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001672766,"threshold_uncertainty_score":0.005595982,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01045191668035349,"score_gpt":0.2356126653979197,"score_spread":0.2251607487175662,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}