{"id":"W4378470736","doi":"10.1186/s12987-023-00437-0","title":"Mouse embryonic stem cell-derived blood–brain barrier model: applicability to studying antibody triggered receptor mediated transcytosis","year":2023,"lang":"en","type":"article","venue":"Fluids and Barriers of the CNS","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada; Natural Sciences and Engineering Research Council of Canada","funders":"","keywords":"Transcytosis; Blood–brain barrier; Cell biology; Stem cell; Tight junction; Induced pluripotent stem cell; Biology; Endothelial stem cell; Embryonic stem cell; Receptor; Drug delivery to the brain; In vitro; Neuroscience; Endocytosis; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004937717,0.0003221972,0.0005143733,0.0001456037,0.0007382996,0.00005523154,0.0005181404,0.000141984,0.00006953783],"category_scores_gemma":[0.0004787346,0.0002257411,0.0002185998,0.001114378,0.0003727007,0.00013041,0.0002836386,0.0002550533,0.00001778632],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000276551,"about_ca_system_score_gemma":0.0001009168,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001535733,"about_ca_topic_score_gemma":0.00000603126,"domain_scores_codex":[0.9975865,0.0002458861,0.0004467675,0.0007395167,0.0004803455,0.0005010046],"domain_scores_gemma":[0.9984071,0.0003932358,0.0001098738,0.000649748,0.00007955264,0.000360506],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000122861,0.00002608587,0.0008640618,0.00005615205,0.00004267599,9.91383e-7,0.003583112,0.0002546213,0.9907025,0.0000795829,0.003867643,0.0003997775],"study_design_scores_gemma":[0.001320224,0.0001925943,0.0007182112,0.00002263534,0.0001015324,0.000002095086,0.002147411,0.002468185,0.9889202,0.0001487572,0.003594542,0.0003636127],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994946,0.0001124282,0.0005733916,0.002142208,0.000367578,0.0008226138,0.0005720399,0.0002185157,0.0002452099],"genre_scores_gemma":[0.9968901,0.0001646741,0.00007812907,0.001010188,0.00005131347,0.0000892208,0.000005912711,0.00004286411,0.001667542],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002213563,"threshold_uncertainty_score":0.9205457,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0249029631069974,"score_gpt":0.2550741029848799,"score_spread":0.2301711398778825,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}