{"id":"W4378471763","doi":"10.1038/s41598-023-35662-y","title":"Phase I randomized, observer-blinded, placebo-controlled study of a SARS-CoV-2 mRNA vaccine PTX-COVID19-B","year":2023,"lang":"en","type":"article","venue":"Scientific Reports","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sinai Health System; Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute; University of New Brunswick; University of Toronto; Canada Research Chairs; Providence Health Care","funders":"National Research Council Canada; Canadian Institutes of Health Research; Sunnybrook Research Institute","keywords":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Coronavirus disease 2019 (COVID-19); Placebo; 2019-20 coronavirus outbreak; Double blinded; Medicine; Virology; Messenger RNA; Randomized controlled trial; Betacoronavirus; Immunology; Internal medicine; Biology; Pathology; Gene; Outbreak","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003072057,0.002900881,0.0049164,0.0007608232,0.000908701,0.001265248,0.00145752,0.002735559,0.006862845],"category_scores_gemma":[0.003316052,0.001474743,0.00111611,0.000605623,0.002440944,0.00164457,0.0005601897,0.003445514,0.001381383],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008042617,"about_ca_system_score_gemma":0.002145987,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000700085,"about_ca_topic_score_gemma":0.001505921,"domain_scores_codex":[0.9984233,0.0006860069,0.0001150046,0.0003552558,0.0001378456,0.0002825653],"domain_scores_gemma":[0.997759,0.0005388802,0.0005258073,0.0002759854,0.0002846957,0.0006155646],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9693596,0.02056698,0.0002748702,0.000290142,0.0002376629,0.00001858741,0.0000476639,0.000153375,0.003787579,0.00007947921,0.0004202914,0.004763766],"study_design_scores_gemma":[0.8409246,0.1569309,0.0006948828,0.00001543512,0.0001325818,0.00001203959,0.00001533822,0.0002071299,0.0004939963,0.0001067593,0.000454596,0.00001166155],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9499213,0.002395409,0.002366059,0.0006282839,0.001387064,0.03851144,0.001604349,0.0003232379,0.002862853],"genre_scores_gemma":[0.933587,0.002524723,0.00540977,0.00183698,0.001419745,0.04713655,0.001501532,0.00008453661,0.006499186],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006862845,"threshold_uncertainty_score":0.02295852,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08975603690269242,"score_gpt":0.4013343415199742,"score_spread":0.3115783046172818,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}