{"id":"W4378471985","doi":"10.3390/curroncol30060402","title":"Real-World Outcomes of Stage IV NSCLC with PD-L1 ≥ 50% Treated with First-Line Pembrolizumab: Uptake of Second-Line Systemic Therapy","year":2023,"lang":"en","type":"article","venue":"Current Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; CancerCare Manitoba","funders":"BC Cancer Foundation","keywords":"Pembrolizumab; Medicine; Internal medicine; Systemic therapy; Lung cancer; Stage (stratigraphy); Cohort; Retrospective cohort study; Oncology; Progression-free survival; Cancer; Chemotherapy; Surgery; Immunotherapy; Breast cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006603336,0.0002039905,0.0003214029,0.000369019,0.0003170532,0.0006347225,0.0003138076,0.0003582503,0.00124131],"category_scores_gemma":[0.0017821,0.0001739968,0.0004983907,0.0004157897,0.0002287109,0.0005548886,0.0003621956,0.0003638506,0.000210902],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007707381,"about_ca_system_score_gemma":0.0003927153,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001592137,"about_ca_topic_score_gemma":0.001931881,"domain_scores_codex":[0.9995531,0.000117795,0.00006178809,0.0001343592,0.00006750008,0.00006536831],"domain_scores_gemma":[0.9984067,0.0002102008,0.001013942,0.0000902522,0.0001160932,0.0001628991],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001321064,0.0001079844,0.9967005,0.00001833846,0.00009889995,0.00009154823,0.00002976112,0.0001411221,0.0001965587,0.00001203476,0.00007448144,0.001207791],"study_design_scores_gemma":[0.00008895736,0.001154861,0.9969331,0.000007951377,0.00009161772,0.0006136001,0.00009285101,0.0004305773,0.0002414475,0.00002086773,0.000316564,0.000007591397],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993392,0.0001063367,0.0000419276,0.00001187494,0.000002312396,0.0000120208,0.0003543412,0.000001242398,0.0001308363],"genre_scores_gemma":[0.9993356,0.00003226255,0.00003458297,0.000006886496,0.000005030427,0.00001428903,0.0005320805,5.593059e-7,0.00003875969],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001592137,"threshold_uncertainty_score":0.005592108,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08688624052559522,"score_gpt":0.3781644631220842,"score_spread":0.2912782225964889,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}