{"id":"W4378472172","doi":"10.1038/s41467-023-38196-z","title":"Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population","year":2023,"lang":"en","type":"review","venue":"Nature Communications","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; BC Cancer Agency; Lunenfeld-Tanenbaum Research Institute","funders":"National Cancer Institute; National Human Genome Research Institute; Cancer Institute and Hospital, Chinese Academy of Medical Sciences; University of Colorado Denver; University of California, Los Angeles; National Institutes of Health; National Research Program for Biopharmaceuticals; Ministry of Science and Technology, Taiwan; Ministry of Education, India; China Medical Board; Ministry of Science, ICT and Future Planning; National Health and Family Planning Commission of the People's Republic of China; Johns Hopkins University; Ministry of Health, Labour and Welfare; National Key Research and Development Program of China; National Science Council; Natural Science Foundation of Guangdong Province; Medical Research Council; National Research Foundation of Korea; National High-tech Research and Development Program; Agency for Science, Technology and Research; Program for Changjiang Scholars and Innovative Research Team in University; Higher Education Discipline Innovation Project; National Research Foundation; U.S. Public Health Service; University of Alabama; National Medical Research Council; University of Utah; University of Alabama at Birmingham; World Health Organization; Cancer Research UK; Henry Ford Health System; American Cancer Society; Georgetown University; National Natural Science Foundation of China; University of Pittsburgh; Government of Jiangsu Province; National Science Foundation; University of Minnesota; Sookmyung Women's University","keywords":"Genome-wide association study; East Asia; Population; Genome; Biology; Genetic association; Association (psychology); Genetics; Medicine; Geography; Gene; Single-nucleotide polymorphism; Genotype; Environmental health; China; Psychology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001203745,0.00054641,0.001314773,0.001761017,0.0001295494,0.0005746051,0.0004980481,0.0006123395,0.001194983],"category_scores_gemma":[0.0008971855,0.0001719422,0.000515544,0.002581618,0.0003222948,0.0003249305,0.0004521695,0.0007884894,0.0004732607],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003979027,"about_ca_system_score_gemma":0.0007710187,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002940774,"about_ca_topic_score_gemma":0.002700354,"domain_scores_codex":[0.9997284,0.00007310395,0.00004310657,0.00006221226,0.00007321684,0.00002001524],"domain_scores_gemma":[0.9995316,0.0002127,0.00009264453,0.00001451468,0.0001042008,0.00004417609],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.0006770584,0.00006120106,0.01551452,0.01816842,0.001915483,0.0007367737,0.00008914353,0.0004719598,0.001690276,0.001492275,0.01297112,0.9462118],"study_design_scores_gemma":[0.0003805697,0.001061462,0.2358766,0.01855253,0.008208824,0.009569108,0.0003901896,0.001019839,0.002492861,0.004584834,0.7177051,0.0001581509],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0007130249,0.9986129,0.00008379094,0.0001782792,0.00007612971,0.000001930533,0.00003186141,0.00000407276,0.0002979806],"genre_scores_gemma":[0.007950015,0.991302,0.0001449021,0.0001731749,0.0001539687,0.000006505504,0.00007662072,0.000001716078,0.0001910587],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002940774,"threshold_uncertainty_score":0.006366074,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04341864504095632,"score_gpt":0.3667232639670081,"score_spread":0.3233046189260518,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}