{"id":"W4378473515","doi":"10.1016/j.jdin.2023.05.006","title":"Real-world effectiveness and safety of risankizumab in patients with plaque psoriasis in whom guselkumab failed recently: A multicenter retrospective study of switching within the interleukin-23 inhibitor class","year":2023,"lang":"en","type":"article","venue":"JAAD International","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's College Hospital; Probity Medical Research; SKiN Health; Dermatrials Research; Sunnybrook Health Science Centre; Health Sciences Centre; University of Calgary; University of Toronto","funders":"","keywords":"Medicine; Interleukin 23; Psoriasis; Plaque psoriasis; Dermatology; Multicenter study; Interleukin 17; Internal medicine; Randomized controlled trial; Cytokine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002449322,0.0002772987,0.0009431748,0.0007347087,0.0003608667,0.0009336002,0.0005492022,0.0008337486,0.001850226],"category_scores_gemma":[0.01264296,0.0003186684,0.0009120521,0.001439105,0.0004083959,0.0008554155,0.0003420257,0.0009416447,0.0002757893],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003929184,"about_ca_system_score_gemma":0.0004704446,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009441503,"about_ca_topic_score_gemma":0.0007118566,"domain_scores_codex":[0.9979061,0.0006268097,0.000480203,0.0005340124,0.000293467,0.0001593956],"domain_scores_gemma":[0.9822773,0.006409171,0.007811749,0.001233721,0.00132453,0.0009435348],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002331399,0.0002203314,0.988476,0.000324084,0.0008229878,0.00081738,0.0002259392,0.00004711563,0.0002145583,0.00004546557,0.001279891,0.005194873],"study_design_scores_gemma":[0.000690065,0.003098907,0.9812173,0.0003763636,0.002347535,0.007011473,0.0006225769,0.0005497498,0.0004025795,0.0001356819,0.003486982,0.00006070777],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992508,0.005317647,0.0001281476,0.0004557199,0.0000870401,0.00003794331,0.001034049,0.0000054453,0.0004258809],"genre_scores_gemma":[0.9974094,0.0009347538,0.0001349225,0.0004194065,0.0003134095,0.0000288206,0.0006600613,0.000005815415,0.00009347141],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002449322,"threshold_uncertainty_score":0.0129534,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008630439969146362,"score_gpt":0.2453997411376649,"score_spread":0.2367693011685185,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}